Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro
Abstract
Majed H. Karbon, Ali H. Alhammer.
There is an increasing interest nowadays in using medicinal plants to treat and prevent cancer. This study aimed to investigate the anticancer activity of aqueous-ethanol extract of Typha domingensis (Pers) (Pollen), a plant that grows widely in the marsh’s areas south of Iraq. The cytotoxic effect was tested on two breast cancer cell lines MCF7 and MDA-MB231 in vitro for 24 hours’ exposure. 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay was utilized to test the effect of pollen extract on cells proliferation. Results showed that MCF7 cells, estrogen receptor + (ER+), were sensitive (GI50 = 254μg/ml) to pollen extract and this effect was confirmed morphologically under microscope, however, MDA-MB231 (ER-) cells were greatly resistant to the same extract. It can be concluded that aqueous ethanolic extract of Typha domingensis (Pers) (Pollen) may offer a therapeutic candidate against ER+ breast cancer cells.
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| Pubmed Style Karbon MH, Alhammer AH. Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. SRP. 2020; 11(10): 1158-1161. doi:10.31838/srp.2020.10.167 Web Style Karbon MH, Alhammer AH. Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. http://www.sysrevpharm.org/?mno=57012 [Access: March 30, 2021]. doi:10.31838/srp.2020.10.167 AMA (American Medical Association) Style Karbon MH, Alhammer AH. Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. SRP. 2020; 11(10): 1158-1161. doi:10.31838/srp.2020.10.167 Vancouver/ICMJE Style Karbon MH, Alhammer AH. Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. SRP. (2020), [cited March 30, 2021]; 11(10): 1158-1161. doi:10.31838/srp.2020.10.167 Harvard Style Karbon, M. H. & Alhammer, . A. H. (2020) Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. SRP, 11 (10), 1158-1161. doi:10.31838/srp.2020.10.167 Turabian Style Karbon, Majed H., and Ali H. Alhammer. 2020. Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. Systematic Reviews in Pharmacy, 11 (10), 1158-1161. doi:10.31838/srp.2020.10.167 Chicago Style Karbon, Majed H., and Ali H. Alhammer. "Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro." Systematic Reviews in Pharmacy 11 (2020), 1158-1161. doi:10.31838/srp.2020.10.167 MLA (The Modern Language Association) Style Karbon, Majed H., and Ali H. Alhammer. "Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro." Systematic Reviews in Pharmacy 11.10 (2020), 1158-1161. Print. doi:10.31838/srp.2020.10.167 APA (American Psychological Association) Style Karbon, M. H. & Alhammer, . A. H. (2020) Cytotoxic Effect of Aqueous-Ethanol Extract of Typha Domingensis Pers. (Pollen) against Human Breast Cancer Cells in Vitro. Systematic Reviews in Pharmacy, 11 (10), 1158-1161. doi:10.31838/srp.2020.10.167 |
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