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Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits

Abstract

Hawraa M. Murad, Shurooq Asaad Abdulameer, Dhuha Salman Asker Aljuboory, Dheyaa A. Neamah, Ali Hamza Maktouf.

Current research has determined the protective role of Berberine (BRB) in the reproductive toxicity induced by cypermethrin (CYP) in male rabbits, Twenty adult New Zealand white rabbits were randomized into four main groups: group I (control group ) received (1 ml / kg b.w saline orally), group II received (CYP64mg / kg b. w./orally); group III (received BRB 50 mg / kg b. w./plus CYP64mg / kg b.w orally); and group IV (received BRB 100 mg / kg b. w plus CYP64mg.kg b. w orally) received all oral gavage therapies for 21 consecutive days. On the (22) day of the experiment, all the rabbits were scarified, and then samples were taken of the blood, testis and caudal epididymis. CYP exposures were found to have substantial adverse effects on the reproductive system of adult male rabbits as a result of decreased testicular and epididymal weight, a significant decrease (p<0.05) in serum testosterone (T) and increase significantly in follicle stimulating hormone ( FSH), luteinizing hormone ( LH), Changes and histopathological ones. BRB has a substantial improvement in T, FSH and LH (p < 0.01) and enhances tissue morphology in BRB (50 mg/kg), while BRB (100 mg/kg) has more reproductive system curative ability. These findings indicate that CYP-induced reproductive system toxicity in rabbits can be covered by BRB (100 mg/kg) antioxidant impact.

How to Cite this Article
Pubmed Style

Murad HM, Abdulameer SA, Aljuboory DSA, Neamah DA, Maktouf AH. Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. SRP. 2020; 11(9): 841-846. doi:10.31838/srp.2020.9.120

Web Style

Murad HM, Abdulameer SA, Aljuboory DSA, Neamah DA, Maktouf AH. Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. http://www.sysrevpharm.org/?mno=20544 [Access: March 31, 2021]. doi:10.31838/srp.2020.9.120

AMA (American Medical Association) Style

Murad HM, Abdulameer SA, Aljuboory DSA, Neamah DA, Maktouf AH. Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. SRP. 2020; 11(9): 841-846. doi:10.31838/srp.2020.9.120


Vancouver/ICMJE Style

Murad HM, Abdulameer SA, Aljuboory DSA, Neamah DA, Maktouf AH. Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. SRP. (2020), [cited March 31, 2021]; 11(9): 841-846. doi:10.31838/srp.2020.9.120


Harvard Style

Murad, H. M., Abdulameer, . S. A., Aljuboory, . D. S. A., Neamah, . D. A. & Maktouf, . A. H. (2020) Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. SRP, 11 (9), 841-846. doi:10.31838/srp.2020.9.120


Turabian Style

Murad, Hawraa M., Shurooq Asaad Abdulameer, Dhuha Salman Asker Aljuboory, Dheyaa A. Neamah, and Ali Hamza Maktouf. 2020. Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. Systematic Reviews in Pharmacy, 11 (9), 841-846. doi:10.31838/srp.2020.9.120


Chicago Style

Murad, Hawraa M., Shurooq Asaad Abdulameer, Dhuha Salman Asker Aljuboory, Dheyaa A. Neamah, and Ali Hamza Maktouf. "Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits." Systematic Reviews in Pharmacy 11 (2020), 841-846. doi:10.31838/srp.2020.9.120


MLA (The Modern Language Association) Style

Murad, Hawraa M., Shurooq Asaad Abdulameer, Dhuha Salman Asker Aljuboory, Dheyaa A. Neamah, and Ali Hamza Maktouf. "Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits." Systematic Reviews in Pharmacy 11.9 (2020), 841-846. Print. doi:10.31838/srp.2020.9.120


APA (American Psychological Association) Style

Murad, H. M., Abdulameer, . S. A., Aljuboory, . D. S. A., Neamah, . D. A. & Maktouf, . A. H. (2020) Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. Systematic Reviews in Pharmacy, 11 (9), 841-846. doi:10.31838/srp.2020.9.120

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