Derangement in Lipid profile &renal function in hypothyroid Iraqi patient.

Abstract

Zainab A. Razak Al-Sharifi, Satar M Kadam.

Background: thyroid dysfunction is often related with the disturbed mineral metabolism and dyslipidemia. Kidney dysfunction in the hypothyroidism appears to be related to thyroid hormone levels decrease rather than thyroid autoimmunity.
Aim of study: investigate the deterioration in renal function test & lipid profile in Iraqi patients with primary hypothyroidism.
Subjects & methods: 143 patients with primary hypothyroidism with 155 healthy subjects as control group were selected. The measurements of thyroid stimulating hormone (TSH), free thyroxine (FT 4), and free tri-iodothyronine (FT 3), were achieved. Triglyceride, serum total cholesterol, LDL-cholesterol, HDL-cholesterol, blood urea, glucose, serum creatinine with serum calcium & phosphorus were measured for both patients & controls.
Results: this study showed significant increase in blood urea, serum creatinine, cholesterol, triglyceride and LDL-cholesterol in patients compared with control group, while serum calcium and HDL-cholesterol were significantly decline in patients in comparison with controls.
Conclusion: hypothyroidism may be an under-appreciated reason for renal impairment and dyslipidemia.