Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution
Abstract
Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady
This study include a spectroscopic measurements of Stavudine diffusion in cell membrane alternative model in two different polar solutions; buffer phosphate solution (Polar solution) and N-Hexane (Non-polar solution). Consistent with the standard values, a clear maximum absorption peaks at 266 nm was noted for Stavudine in buffer phosphate solution. The data also showed that the value of the extension coefficient and �max reduced in the non-polar medium compare to polar medium which was noted a s a part of the spectroscopic properties of Stavudine in polar and non-polar medium. Stavudine express a high stability with time in pH 7.4 .
SDS was used as a cell membranes substitute model, and the diffusion rate of Stavudine through SDS micelles solution (with a concentration of 0.2 ×10-2 M)was examined. The chemical potential was calculated which was equal to -2489.4 J mol-1which indicate the impulsiveness of the diffusion process for the compound. The results suggested that Stavudine can diffuse (in a rate constant of 0.0183 min-1) to inside micelle from the aqueous medium. Of other detected factors; the equilibrium constant for diffusion rate was detected and was equal to 2.7313.
| How to Cite this Article |
| Pubmed Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Web Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. http://www.sysrevpharm.org/?mno=112584 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.17 AMA (American Medical Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Vancouver/ICMJE Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. (2020), [cited March 29, 2021]; 11(6): 96-100. doi:10.31838/srp.2020.6.17 Harvard Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 Turabian Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. 2020. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 Chicago Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11 (2020), 96-100. doi:10.31838/srp.2020.6.17 MLA (The Modern Language Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11.6 (2020), 96-100. Print. doi:10.31838/srp.2020.6.17 APA (American Psychological Association) Style Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17 |
Abstract
PDF
How to cite this article
Related Records