Determination of the Ciprofloxacin Hydrochloride Drug in Some Pharmaceuticals using Manufactured Membrane Selective Electrodes

Abstract

Abdul Majeed K. Ahmed, Imad Tarek Hanoon, Seemaa Hameed Ahmed.

This research includes estimation of the Ciprofloxacin Hydrochloride drug using manufactured liquid selective membranes electrodes , where the selective electrodes of drug were prepared from the Active ingredient with Sodium tetra phenyl borate and using organic plasticizer (Di-n-butyl phthalate, DBPH) with (poly vinyl chloride, PVC) as a substrate. The results indicated that the tendency of the electrode CIP-STPB is 29.4 mV / decade at a range of the PH (2.5-4.0) and the electrode response was good for the concentrations of the pharmaceutical drug and the concentration was 10-1-10-4 molar, correlation coefficient 0.994, detection limit 2.5 x 10-8 µg.ml-1 and the electrode life time was fourteen days, and the electrode selectivity was measured with mono- and Dual-compounds and ions, and the electrode proved successful by estimating the drug with a regenerative not less than 98%.