Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes
Abstract
Helmy AS, ELMeneza SA, ELBagoury IM
Background: Neonatal sepsis is an important cause of morbidity and mortality.
Aim of work: Study the diagnostic value of early-onset sepsis risk calculator (EOSR) and vitamin D as markers for early diagnosis of sepsis among the newborn infants > 34 weeks who were exposed to premature rupture of membrane (PROM).
Patients and Methods: This observational case-control study included 100 newborn infants > 34 weeks of gestation. Newborn infants were assigned into two groups according to the development of sepsis and exposure to PROM: septic and control groups. Kaiser EOSR calculator was used. Vitamin D was estimated by ELISA.
Results: There was a significant increase of EOSR calculator mean values in the septic group than the control group at birth and after clinical examination. The median ± IQR was 10.26 (5.3-24) per 1000/birth at birth in the sepsis group and 0.47(0.39 – 0.67) in the control group. EOSR calculator was 63.2 (25.5 – 142.6) per 1000/births after clinical examination in the septic group and 0.19(0.16 – 0.27) in the control group, P-value was < 0. 001. There was a significant decrease in vitamin D in the septic group (8.57 ± 9.14 ngL) than the control group (50.61 ± 12.55ngL), the P-value was <0.001.
Conclusion: Early-onset sepsis risk calculator and vitamin D have high sensitivity and specificity in predicting sepsis among infants exposed to PROM, these may decrease the unnecessary use of prophylactic antibiotics among infants > 34 weeks of gestation. Estimation of vitamin D in neonates with equivocal EOSR calculator score may assist in the early management.
How to Cite this Article |
Pubmed Style AS H, SA E, IM E. Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. SRP. 2021; 12(1): 1375-1380. doi:10.31838/srp.2021.1.194 Web Style AS H, SA E, IM E. Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. http://www.sysrevpharm.org/?mno=51937 [Access: March 31, 2021]. doi:10.31838/srp.2021.1.194 AMA (American Medical Association) Style AS H, SA E, IM E. Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. SRP. 2021; 12(1): 1375-1380. doi:10.31838/srp.2021.1.194 Vancouver/ICMJE Style AS H, SA E, IM E. Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. SRP. (2021), [cited March 31, 2021]; 12(1): 1375-1380. doi:10.31838/srp.2021.1.194 Harvard Style AS, H., SA, . E. & IM, . E. (2021) Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. SRP, 12 (1), 1375-1380. doi:10.31838/srp.2021.1.194 Turabian Style AS, Helmy, ELMeneza SA, and ELBagoury IM. 2021. Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. Systematic Reviews in Pharmacy, 12 (1), 1375-1380. doi:10.31838/srp.2021.1.194 Chicago Style AS, Helmy, ELMeneza SA, and ELBagoury IM. "Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes." Systematic Reviews in Pharmacy 12 (2021), 1375-1380. doi:10.31838/srp.2021.1.194 MLA (The Modern Language Association) Style AS, Helmy, ELMeneza SA, and ELBagoury IM. "Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes." Systematic Reviews in Pharmacy 12.1 (2021), 1375-1380. Print. doi:10.31838/srp.2021.1.194 APA (American Psychological Association) Style AS, H., SA, . E. & IM, . E. (2021) Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes. Systematic Reviews in Pharmacy, 12 (1), 1375-1380. doi:10.31838/srp.2021.1.194 |