Effect of different doses of L-carnitine on fertility of the male reproductive system of albino rats

Abstract

Rashid Khamees Shaban, Noor Ibrahem Hasan AL-Kraie, Qasim Azeez Razooqi.

In the current study, different doses of L-carnitine were tested on 20 healthy albino male rats to determine the effect of L-carnitine on the physiological and histological parameters of the reproductive system. The animals were distributed into four groups, the first group was the control group. In this group the animals were not given any dose of L-carnitine, The second group was the treatment group and in this group the animals were dosed with L-carnitine at a dose of 28 mg / kg, and the third group was the double dose group, as the animals dosed 56 mg / kg of carnitine, while the fourth group was dosed with an overdose when they were dosed with 112 mg / kg of L- carnitine .
The results of the hormonal study showed that the double dose and the double dose group led to a significant decrease in the level of ICSH, SSH and testosterone, while the treatment group had no significant differences compared to the control group. The treatment group did not notice significant differences in the level of male hormones compared with the control group.
The results of the study showed that the sperm parameters of the treated group were normal, while the sperms in the double and excessive group of L-carnitine showed the presence of twisted tailed sperm and the occurrence of deformation in the sperm head. The testicular tissue sections in the L-carnitine treatment group showed normal spermatogenesis during spermatogenesis, spermatogenesis and Leydig cells, while the L-carnitine double group showed a low number of mature sperms. Also, in the testicular sections of the doubled L-carnitine group, the occurrence of histological necrosis of the testicles was found. Additionally, the stages of spermatogenesis are not clear.