EFFECT OF GIVING ETHANOL JENGKOL SEEDS (Pithecellobium lobatum Benth.) ON THE IMPROVEMENT OF UREUM AND CREATININE LEVELS OF WHITE RAT
Evi Kurniawaty, Frisca Febe Lumban Gaol, Intanri Kurniati, Silvia Andriani, Soraya Rahmanisa, Silvia Andriani.
Purpose: Diabetes Mellitus is a degenerative disease which is a chronic disease caused by the failure of the pancreas to produce insulin. Diabetes Mellitus is characterized by polyuria, polydipsia, and polyphagia, accompanied by an increase in blood glucose. Diabetes mellitus triggers many complications, one of which is kidney problems. Jengkol is a type of plant that can lower blood sugar levels, but it can also cause acute kidney failure due to the jengkolic acid content in it. To diagnose acute renal failure, it is necessary to examine kidney function by measuring levels of urea and creatinine.
Research Methodology: This research is an experimental study with a Post Test Only Control Group Design. The sample in this study were male white rats (Rattus novergicus) Sparague Dawley strain with a body weight of 200-250 grams, aged 3-4 months, totaling 25 animals, which were divided into 5 groups.
Results: Based on the results of the oneway ANOVA test, it was found that the p value> 0.05 jengkol seed extract had no effect on the increase in urea and creatinine levels of sparague dawley rats induced by alloxan. However, when viewed from the mean creatine level at a dose of 1200 mg / kgbb, the ethanol extract of jengkol seeds can cause an increase in creatinine levels with a group mean value of 0.08mg / dl.
Limitations: This research is expected to be the basis for further researchers regarding jengkol extract as a therapy for kidney failure
Contribution: Bandar lampung, Biologi Molekul