Effect of using Bone Marrow Stromal Cells on Uterine Involution in Iraqi Ewes

Abstract

A.A.Omar, T.R. Mohammed, Salah M.A.AL-Kubaisi.

During involution the uterus in ewes undergoes a clear remodeling; unfortunately, information on cellular and molecular activities that controls this interval is inadequate. The working hypothesis of this study applied in, is that uterus returns to a non-pregnant status during involution, involves the proliferative and regeneration activity of mesenchymal stem cells (MSCs) which migrated to the uterus servomechanism that regulates and remodeling endometrial gland epithelial surface postpartum. The present study consist of 15 Iraqi local breed ewes were divided equally into three groups. The 1st and 2nd group were injected intravenously with bone marrow stromal cells (BMSCs) in a doses 1×108, 2×108 respectively, 48 hours postpartum, while the 3rd group served as a control group. Uterine biopsy were taken at 7, 15, 17 and 21 days postpartum, and processed to histopathological examination. The progressive of involution was clearly observed in treated groups till ended at days 21 for 2nd group, as well as in the 1st group but in a lesser extent. It was concluded that BMSCs has a beneficial effect on uterine involution which is completed at day 21in Iraqi ewes.