Effect Study A Nonsteroidal Antiinflammatory Drug (Indomethacin) on Fertility, Some Reproductive Norms and Histological Changes of Fetuses and Newborns of Administered Albino Rats Before Pregnancy

Abstract

Dalal Abdel-Hussein Kadhim AL– Essawi.

This study was executed in animal house of Education Faculty for girls –kufa university for 1-8-2020 to 1-11-2020 for detecting the effects of a nonsteroidal antiinflammatory drug (indomethacin) on fertility, some reproductive norms and histological changes of some organs of fetuses and newborns of administered albino rats before gestation, female and male albino white rats were used in this study with age rate (3months and 2.5 months) and weight rate(240 gm and 236 gm) respectively,the animal rats were divided into two groups:the first group was treated with normal saline and represented control group,the second group was treated with indomethacin drug before the pregnancy as following: The female and male rats were administered with indomethacin with concentration of 15 mg /kg of body weight for 30 days and 50 mg /kg of body weight for 60 days respectively, all experiment animals were administered orally one dose before mating by rat stomach tube before wiving,after that the animal rats were mated and left to the pregnancy,then some of the pregnant rats were dissected during 20 days period of the pregnancy,while the others renounced to the birth of study two groups. The results indicated that there was no influence on the fertility of male and female rats that were treated with indomethacin drug before pregnancy, pregnant female rats that were treated with indomethacin before pregnancy suffered from some cinical signs such as diarrhea, loss of appetite and lethargy during pregnancy,as the bleeding was observed during the birth in female rats compared with control group, the results recorded a significant reduce (P <0.05) in numbers of gross and living fetuses for (20)days of pregnancy and nweborns after birth , while numbers of absorbed fetuses for (20)days of pregnancy and newborns after birth significantly increased (P <0.05) in treated animals with indomethacin before pregnancy compared with control group, as wall as the result of current study showed that a significant reducing (P <0.05) in the weight of body and lengths of body,tail and limbs of fetuses for (20)days of pregnancy and newborns after birth in treated group with indomethacin before pregnancy when compared with control group,and also the treatment with indomethacin caused patho-histological changes in livers and kidneys of fetuses for (20)days of pregnancy and newborns after birth compared with control group. We conclude of this study that indomethacin which is one of the nonsteroidal antiinflammatory drugs that was administered to animal rats before pregnancy may have a cumulative effect inside the body making its harmful effects extend to the fetuses during pregnancy and newborns after birth.