Effects of a Cellular Camel Urinary Bladder Sub Mucosa on Chronic Full Thickness Skin Wound Healing in Equine Species

Abstract

Ahmed Kassem, Ayad N.D. Alhaki, Abd-Alhadi Jaithom Marzok.

This study is designed to assess the effectiveness of Camel sub mucosa which extracted from urinary bladder on healing of chronic cutaneous wound in Equine species. A 20 (5X4) cm of full- thickness wounds were induced in three donkeys, two wounds on each side of the adjacent pelvic region. Wounds were isolated into two equal groups (each 3wounds/ one group); treatment group included the wounds on the three side which were treated by covering the wound beds with strips of a cellular sterilized camel urinary bladder matrix. While the wounds on the left side were left without any treatment (control group). The results were evaluated clinically (along) and histopathologically on 20 days post-inducing of wounds. The clinical examination of treated wounds appeared that the wound healing process re-epithelization %, contraction% and total wound healing %were P<0.05 significantly than that of control wounds at 20 days of the study. The histopathological valuation confirmed that urinary bladder matrix treated wounds have improved cellularity, enhance vasculature, thick and large granulation tissue proposing improved cutaneous wound healing, comparison with untreated wounds. According to the clinical observation and histopathological results, this study concluded that a cellular camel urinary bladder matrix play an important role in stimulation of cutaneous wound healing of donkeys without signs of immune rejection.