Efficacy And Safety Of Trombless« Neo And Detralex« In The Treatment Of Chronic Venous Diseases Are The Results Of An Open-Label, Comparative, Multicenter Randomized Prospective Study

Abstract

G.N. Gildeeva, A.V. Belostotsky, O.V. Gridnev, V.I. Yurkov.

Chronic venous diseases (CVD) of the lower limbs are an acute medical and social problem due to their widespread distribution among a significant part of the population, and patients rarely seek medical help in the early stages of the disease. Medication based on micronized purified flavo¬noid fraction (PMFF) play a leading role in the elimination of CVD symptoms of lo¬wer limbs. The article presents the results of a multi-center open randomized clinical study conducted in Russia on the efficacy and safety (phase III) of the generic drug Trombless® Neo (diosmin+hesperidin) in comparison with the reference product Detralex® with the participation of 130 patients with symptomatic CVD of lower limbs C2-C3 class of the CEAP classification. The results of the study indicate no less efficacy and comparable safety of Trombless® Neo in relation to changes (decrease) in the severity of CVD symptoms after a 60-day course of therapy.

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 ┬╗ doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 ┬╗ doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to ÔÇťHealthcare for AllÔÇŁ Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 ┬╗ doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 ┬╗ doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 ┬╗ doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 ┬╗ doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 ┬╗ doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to ÔÇťHealthcare for AllÔÇŁ Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 ┬╗ doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 ┬╗ doi: 10.5530/srp.2019.1.3