Estimate Toxic Effect Of Silica Nanoparticles On Kidney, Liver And Lung Function Of Male Albino Rats

Abstract

Leena Adeeb Mehdi, Alaa Mohammad Hasson Al-Husseini.

The current study was carried out in the animal house of faculty of science/Kufa university on thirty male albino rats to determine the toxic effect of nano silica on some organs, kidney, lungs and liver in the male adult rats that treated with two concentrations (100,150)mg/kg of silica nanoparticles for 30 days. the kidney and liver functions were determined by biochemical markers (AST, ALT, Urea and Creatinine), and histopathological analysis was performed to all studied organs .the results showed a significant elevation in ALT, AST Urea and Creatinine levels in serum of male rats .the histopathological results showed severe damage in the tissue of kidney, liver and lungs especially at high concentration 150mg/kg. It caused necrosis, dilation in renal tubules and inflammation of hepatocytes, also, there was metaplasia in mucous and hypertrophy in lung tissue, these findings as a response to administration orally of silica nanoparticles.