Evaluation of levels of oxidants and antioxidants stress markers in saliva and serum of patients with recurrent aphthous stomatitis (RAS)

Abstract

Dunia W. Sabea

Background:
Recurrent aphthous stomatitis (RAS) still the most collective aching oral complain with uncertain etiopathology. Saliva is the promising noninvasive diagnostic media used in a lot of biomedical research for investigation and prognosis in many oral and systemic diseases.
Aim of the study:
The present study aimed to assess the interference of most (oxidative and antioxidative) stress factors in both plasma and slaver of group with RAS and of healthy controls and compare between them inside the same patient’s group.
Materials and methods:
Thirty patients with (RAS) their age was (18-55) years old were compare to other thirty (30) healthy controls matching them in age and gender were included in this study. Samples from serum and saliva were taken. Evaluation of both oxidants Malondialdehyde (MDA); and antioxidants; superoxide dismutase (SOD); catalase (CAT); total Glutathione (GSH) and Uric acid (UA) parameters was done. Statistical analysis was done for assessments’ parameters.
Results:
The mean age of patients was (36.53±10.13). Oxidative stress marker was expressively greater in patients than in healthy in both serum and saliva, and in serum more than in saliva within the same RAS group. Measurements of antioxidants markers where considerably greater in serum of healthy than in the illness’s group, and inside same group were more in saliva than in serum.
Conclusions:
Oxidants and antioxidants parameters play a role in RAS pathogenesis, some of them more than the others with interference not completely clear therefore more clinical studies are required.