Evaluation of the Correlation of Trefoil Factor with Hemostatic Profile in Iraqi Diabetic Nephropathy Patients

Abstract

Anwar Abd-Al-Hameed Kamal, Maysaa A. Hadi, Hussein Naji.

In the present study, the percentages of study variables including age, gender, residence, smoking habit, family history, treatment and duration of disease between study groups including patients with diabetic nephropathy, diabetic patients without diabetic nephropathy and control group were results showed presence of significant differences between study groups in age (P 0.007), family history (P<0.001), treatment (P 0.005), and duration of disease (P 0.044), while there were no significant differences between study groups in their gender (p 0.942), residence (p 0.848), and smoking (p 0.958). there were significant increase between means of biomarkers concentrations of those study groups in both smoker and nonsmoker which include trefoil (P 0.011, P 0.002), d-dimer (P 0.011, P 0.002), fibrinogen (P<0.001, P<0.001), According to smoking habit, there was no significant differences (P≤ 0.05) between smokers and non-smokers in all study groups there was significant increase (P 0.017) in trefoil concentration in diabetic without nephropathy group with increasing of duration of disease Furthermore, no significant between D-dimer (p 0.155, p 0.738) fibrinogen (p 0.935, p 0.797). There was significant increase in means of fibrinogen and d-dimer in DN groups with all duration of disease (P 0.013, P 0.002, P 0.021), (P 0.038, P 0.02, P<0.001) compared to DM group. In addition, the results showed presence of significant increase in means of trefoil concentration in DN and DM groups at age group 46-60 years (P<0.001), and there was significant increase of d-dimer concentration for DN and DM groups at age groups 30-45 years and 46-60 years (P 0.011, P 0.007) compared to control. While mean differences of fibrinogen concentration was significant increase in DN and DM groups at age groups 46-60 years and ≥ 60 years (P 0.001, P<0.001) respectively compared to control group. So, there were no significant difference between trefoil concentration in study groups including (diabetic with nephropathy, diabetic without nephropathy and control group) according to age (p 0.858, p 0.116, p 0.252), d-dimer (p 0.268, p 0.506, p 0.527), fibrinogen (p 0.307, p 0.978, p 0.703). There was significant difference between means of all biomarkers in this study for study groups with gender (male and female). These marker trefoil (P 0.001, P 0.018), d-dimer (P 0.002, P 0.005), fibrinogen (P<0.001, <0.001), Furthermore, no significant difference between males and females in all study groups (diabetic with nephropathy, diabetic without nephropathy and control group) including trefoil concentration (p 0.819, p 0.865, p 0.505), d-dimer (p 0.334, p 0.766, p 0.803), fibrinogen (p 0.207, p 0.595, p 0.15).
Objective: This study aimed to investigate the effect of diabetic nephropathy in thrombosis formation and hemostatic profile by study trefoil related with hemostasis