Evaluation of the Effect of Premna Pubescence Extract against DMBA-Induced Breast Cancer in Female

Abstract

Martina Restuati, Ahmad Shafwan S. Pulungan, Nanda Pratiwi, Trifena Pauline Sirait

Notably, the use of premna pubescence has been rooted in Sumatra- Malay philosophy. Besides, consuming the substance has been noted as having an extensive history concerning the supreme curative value and with the accuracy of treating a specific type of sickness that distracts the human bodies. In the context, premna pubescence extract has been noted as being responsible for its curative effects as well as bringing some potential regarding the treatment of cancer. There is a current study concerning the effects of premna pubescence extract of leaves on the pathological modification associated with breast cancer in feminine rats. Thus, the research needs to investigate the effectiveness of this dosage against cancer. In the study, the rats are given a single dose of DMBA using a gastric tube where they receive three times a week for four weeks. According to the study, the ethanol extract of the dose leaves reserved the pathological modifications in mammary nerves of the female rats persuaded by the DMBA handling. The results of the study show that the ethanol extract of the dose had an outcome on the constraining ductal epithelial cell explosion as well as ductal length. Besides, this dosage leaves the ethanol excerpt, which is known as the most operative to hinder pathological modification and measures 450 mg/kg. Also, the results show that the dose has a protective consequence against the cancer of the mammary glands. Hence, the antioxidant chattels of the pubescence leave abstract is facilitated by their actions as well as studying other fundamental mechanisms.