Evaluation the Effect of Pulmicort Inhalation on Children with Acute Asthma Attack

Abstract

Ahmad Bahrami, Shabahang Jafarnejad, Hamidreza khoshnezhad Ebrahimi, Seyedeh Mahsa Mahmoudinezhad Dezfouli, Rozhin Pahlevani.

Background: Asthma is one of the most common chronic diseases in childhood, and acute asthma is the most common emergency and one of the main reasons for hospitalization in children. One in 20 people suffers from asthma around the world.
Objectives: The present study has evaluated the effect of inhaled corticosteroids (Pulmicort), on the symptoms of asthma and hospitalization duration in children with acute asthma attack.
Methods: This study is a randomized clinical trial study had done as a pilot form with a control group (generally 80 children were studied) and is organized as a double blinded. All children have asthma disease and at the first of the study their asthma scores were determined. Then patients are divided into two groups (case and control). Ventolin and hydrocortisone are given to children in both groups. Also, the case group received nebulized budesonide (Pulmicort) and the control received nebulized normal saline (as a placebo).
Results: The mean age among participants is 6.6± 2.8 years old. The difference of sex and age between case and control is not significant. Asthma severity and rate of respiratory between two groups at the first of study were not different too, and both groups were in moderate to severe asthma attack. The differences of wheeze, cough, and distress scores between two groups are significant at 6h, 12h, 24h, and 48h. So that in terms of improving the score of wheezing, cough and respiratory distress in the case group compared to the control group in the mentioned hours are quite significant ( P value: <0.001).The difference of hospitalization time between case and control are significant too (P value <0.001), In a way we saw its duration shortened in a case group.
Conclusion: The study showed that budesonide makes the procedure of the treatment faster and it reduces the duration of the hospitalization. The results showed that the effect of budesonide on patient’s symptoms was positively considerable. In this study no side effect of inhaled corticosteroid was observed during hospitalization. Therefore, it can be a good choice used for the treatment of acute asthma besides the standard guideline of acute asthma treatment.