Exploration of the Relationship Between Interleukin 37 and Folic Acid in Type 2 Diabetic Patients

Abstract

Anwar A. Hussain, Khalid F. Al-Rawi, Aseel Khalid Hameed.

Background: Type 2 diabetes (T2DM) It is a complex disease associated with metabolic disorders. The main aims of the study was to accurately measure the concentration of interleukin (IL-37) and folic acid and explore the possible association between them in T2DM patients and compare it with healthy controls (HCs).
Materials and Methods: Identical in gender and age, 72 diabetics and 16 healthy controls participated in this study; IL-37 serum concentration was estimated by ELISA technique, serum levels of folic acid by electrochemiluminescence method.
Results: An IL-37serum concentration was significantly greater and folic acid serum concentrations lower levels in patients with T2DM compared to HCs, while urea and creatinine didn’t show significant changes between studied groups. There was strong negative relationship among serum IL-37 and folic acid levels in T2DM. but urea and creatinine was presented non-significant association with IL-37 (p > 0.05), however they exhibited a significant association with folic acid (p < 0.05), There was no significant relationship of gender with serum IL-37 & folic acid (both p > 0.05) in patient groups and HCs. Area under curve from Receiver operating characteristic (ROC) analysis, was shown that Interleukin 37 has the highest value compared to all the studied biomarkers.
Conclusion: This study demonstrated the strong negative correlation between IL-37 and folic acid and the important role for them in predicting and monitoring disease and possibly in the treatment of type 2 diabetes patients.