Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient
Abstract
Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar.
This study was designed to assess the anticancer efficacy of TA root extract against human lymphocytic cell-lines of CML and the possible mechanisms for such cytotoxic activity. Eurycoma longifolia Jack is an herbal plant that identified locally as Tongkat Ali (TA) or Pasak Bumbi in Malaysia and Indonesia, respectively. TA has a long documented ethnobotanical history as a health invention. One of the pathogenic malignancy of human hematopoietic stem cells that display an obvious elevation of granulocytes is a chronic myelocytic leukemia (CML) which also manifested with splenomegaly and bone marrow hyperplasia and cause 15-20% of all leukemias.Serial concentrations of 2.5, 5, 10, 20 and 40 μg/mL were prepared form the dried root extracts using dimethyl sulfoxide (DMSO) as a solvent. The potential of cytotoxic effect of TA roots extract against lymphocytes from CML patient reveals steep raise of lymphocytes growth inhibition rate (IR) with TA concentrations. Determination of MDA and SOD activity as well as evaluation of genotoxicity of TA by comet assay, the results confirm that TA has cytotoxic and antiproliferative activity and no genotoxicity at concentration of 10 µg/ml. this give a promising antileukemic activity with different mechanisms of action.
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| Pubmed Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. SRP. 2021; 12(1): 1206-1211. doi:10.31838/srp.2021.1.168 Web Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. http://www.sysrevpharm.org/?mno=48168 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.168 AMA (American Medical Association) Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. SRP. 2021; 12(1): 1206-1211. doi:10.31838/srp.2021.1.168 Vancouver/ICMJE Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. SRP. (2021), [cited March 29, 2021]; 12(1): 1206-1211. doi:10.31838/srp.2021.1.168 Harvard Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar (2021) Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. SRP, 12 (1), 1206-1211. doi:10.31838/srp.2021.1.168 Turabian Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. 2021. Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. Systematic Reviews in Pharmacy, 12 (1), 1206-1211. doi:10.31838/srp.2021.1.168 Chicago Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. "Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient." Systematic Reviews in Pharmacy 12 (2021), 1206-1211. doi:10.31838/srp.2021.1.168 MLA (The Modern Language Association) Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar. "Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient." Systematic Reviews in Pharmacy 12.1 (2021), 1206-1211. Print. doi:10.31838/srp.2021.1.168 APA (American Psychological Association) Style Furqan M. Abdulelah, Mustafa R. Abdulbaqi, Zahraa M. Jaafar (2021) Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient. Systematic Reviews in Pharmacy, 12 (1), 1206-1211. doi:10.31838/srp.2021.1.168 |
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