Follicular Glypican-1 As A Predictive Marker Of Reproductive Outcomes In Women Undergoing IVF/ICSI

Abstract

Ekhlas Ali Hussein, Israa Talib Hassan, May Abdulkareem Abu-Ragheef, Nawar Sahib Khalil, Reem Ali Haddad.

Objectives: The current study aims to determine the relationship between the follicular fluid Glypican-1 levels and the reproductive outcomes in women underwent an In Vitro Fertilization and Intracytoplasmic Sperm Injection (IVF/ICSI).
Methods: The current prospective study includes fifty infertile women who are undergoing IVF/ICSI treatment. Follicular fluid samples are collecting from ovarian follicles for the determination of Glypican-1 levels. Enzyme-linked immunosorbent assays (ELISA) is used to evaluate the expression of Glypican-1 levels. The relationship between follicular Glypican-1 levels and IVF/ICSI outcomes is assessing.
Results: There is a significant difference (p < 0.05) between the follicular Glypican-1 levels in patients who are achieving clinical pregnancy and patients who are remaining non-pregnant (15.3667 ± 5.41264) and (22.8171 ± 9.31019), respectively.
Conclusion: The results of the current study suggest that the levels of follicular fluid Glypican-1 could be a useful predicting marker of IVF/ICSI treatment outcomes.