Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome
Abstract
Ahmed S. Abdul Jabbar, Suhair M. Ashour
Purpose: The present work aims to develop the didanosine loaded stealth liposomes prepared by reverse phase method using Lipoid-S-100 base and DSPE-m-PEG-2000 as stealth forming agent.
Methods: In the process of the development of liposomes, amount of Lipoid-s-100 and cholesterol plays key role and changes the physicochemical properties of liposomes. Then current study focuses on development of different didanosine loaded liposomes screening batches by altering the amount of Lipoid-s-100 and cholesterol using reverse phase technique. The liposomes were evaluated for particle size, zeta potential, percentage of encapsulation and in vitro drug release.
Results: The particle size was found as 287.4 nm, PDI 0.345 and zeta potential was found as – 27.8mV respectively. The assay was found around 100% and the percentage encapsulation was found 89.42±0.9%. The in- vitro release studies of stealth liposomes presented 100 % of drug release up to 28hrs.
Conclusion: The present studies indicated that didanosine liposomes suitable tool for antiretroviral therapy.
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| Pubmed Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . SRP. 2021; 12(1): 884-890. doi:10.31838/srp.2021.1.124 Web Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . http://www.sysrevpharm.org/?mno=45496 [Access: March 31, 2021]. doi:10.31838/srp.2021.1.124 AMA (American Medical Association) Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . SRP. 2021; 12(1): 884-890. doi:10.31838/srp.2021.1.124 Vancouver/ICMJE Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . SRP. (2021), [cited March 31, 2021]; 12(1): 884-890. doi:10.31838/srp.2021.1.124 Harvard Style Ahmed S. Abdul Jabbar, Suhair M. Ashour (2021) Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . SRP, 12 (1), 884-890. doi:10.31838/srp.2021.1.124 Turabian Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. 2021. Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . Systematic Reviews in Pharmacy, 12 (1), 884-890. doi:10.31838/srp.2021.1.124 Chicago Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. "Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome ." Systematic Reviews in Pharmacy 12 (2021), 884-890. doi:10.31838/srp.2021.1.124 MLA (The Modern Language Association) Style Ahmed S. Abdul Jabbar, Suhair M. Ashour. "Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome ." Systematic Reviews in Pharmacy 12.1 (2021), 884-890. Print. doi:10.31838/srp.2021.1.124 APA (American Psychological Association) Style Ahmed S. Abdul Jabbar, Suhair M. Ashour (2021) Formulation And Evaluation Of Antiretroviral Drug Loaded Unsaturated Phospholipid Based Stealth Liposome . Systematic Reviews in Pharmacy, 12 (1), 884-890. doi:10.31838/srp.2021.1.124 |
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