Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.
Abstract
Ganesh R. Pawbake, Satish V. Shirolkar
Diacerein Nanostructured Lipid Carrier (NLC) topical gel was formulated to treat inflammation and the conditions associated with acceleration and prolonged action. Dispersion of nanoparticles was correctly gelled and characterized in pharmacology, pH, proliferation, rheology and in-vitro releases. NLC-based gel safety was assessed with primary skin irritation studies, and pharmacodynamics research confirmed efficacy. Non-steroidal anti-inflammatory drugs (NSAIDs), while known as extreme gastrointestinal and vascular adverse effects without resolving the underlying systemic cartilage injury, are the most widely used agents of osteoarthritis (OA) pain management. Many doctors are elderly. Thus, Diacerein is the preferred drug for strong analgesic benefit in serious OA discomfort. Diacerein is cost-effective and dose-efficient. Gel formulation offers easy application in all quantities at a pain site. The NLC-based gel demonstrated quicker start and extended habits up to 24 hours.
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| Pubmed Style Ganesh R. Pawbake, Satish V. Shirolkar. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. SRP. 2020; 11(6): 794-802. doi:10.31838/srp.2020.6.116 Web Style Ganesh R. Pawbake, Satish V. Shirolkar. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. http://www.sysrevpharm.org/?mno=119067 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.116 AMA (American Medical Association) Style Ganesh R. Pawbake, Satish V. Shirolkar. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. SRP. 2020; 11(6): 794-802. doi:10.31838/srp.2020.6.116 Vancouver/ICMJE Style Ganesh R. Pawbake, Satish V. Shirolkar. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. SRP. (2020), [cited March 29, 2021]; 11(6): 794-802. doi:10.31838/srp.2020.6.116 Harvard Style Ganesh R. Pawbake, Satish V. Shirolkar (2020) Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. SRP, 11 (6), 794-802. doi:10.31838/srp.2020.6.116 Turabian Style Ganesh R. Pawbake, Satish V. Shirolkar. 2020. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. Systematic Reviews in Pharmacy, 11 (6), 794-802. doi:10.31838/srp.2020.6.116 Chicago Style Ganesh R. Pawbake, Satish V. Shirolkar. "Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.." Systematic Reviews in Pharmacy 11 (2020), 794-802. doi:10.31838/srp.2020.6.116 MLA (The Modern Language Association) Style Ganesh R. Pawbake, Satish V. Shirolkar. "Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.." Systematic Reviews in Pharmacy 11.6 (2020), 794-802. Print. doi:10.31838/srp.2020.6.116 APA (American Psychological Association) Style Ganesh R. Pawbake, Satish V. Shirolkar (2020) Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.. Systematic Reviews in Pharmacy, 11 (6), 794-802. doi:10.31838/srp.2020.6.116 |
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