Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery
Abstract
Raditya Weka Nugraheni, Nur Aini Mulyadi, Helmy Yusuf.
Liposomes are one of the means in the drug delivery system that is quite promising because of its ability to carry active ingredients, both hydrophilic and lipophilic. In addition, the structure of lipid bilayers that resemble cell bilayer membranes is useful in optimizing liposomes' ability through increased internalization of active ingredients into cells. However, liposomes themselves are physically and chemically vulnerable systems, so increasing liposome stability is one of the primary considerations in liposome formulations. Lyophilization or freeze-drying can increase the shelf-life of liposomes, but the process itself is very extreme and prone to triggering damage to vesicle structures. Lyoprotectans from sugars and polyols are usually employed to improve the formulations' stability during the drying process. Physical characterization of the liposome end product is done by looking at the system's morphological appearance, crystallinity profile, thermal analysis, and functional group analysis.
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| Pubmed Style Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. 2020; 11(7): 143-151. doi:10.31838/srp.2020.7.23 Web Style Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. http://www.sysrevpharm.org/?mno=121936 [Access: March 30, 2021]. doi:10.31838/srp.2020.7.23 AMA (American Medical Association) Style Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. 2020; 11(7): 143-151. doi:10.31838/srp.2020.7.23 Vancouver/ICMJE Style Nugraheni RW, Mulyadi NA, Yusuf H. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP. (2020), [cited March 30, 2021]; 11(7): 143-151. doi:10.31838/srp.2020.7.23 Harvard Style Nugraheni, R. W., Mulyadi, . N. A. & Yusuf, . H. (2020) Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. SRP, 11 (7), 143-151. doi:10.31838/srp.2020.7.23 Turabian Style Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. 2020. Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. Systematic Reviews in Pharmacy, 11 (7), 143-151. doi:10.31838/srp.2020.7.23 Chicago Style Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. "Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery." Systematic Reviews in Pharmacy 11 (2020), 143-151. doi:10.31838/srp.2020.7.23 MLA (The Modern Language Association) Style Nugraheni, Raditya Weka, Nur Aini Mulyadi, and Helmy Yusuf. "Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery." Systematic Reviews in Pharmacy 11.7 (2020), 143-151. Print. doi:10.31838/srp.2020.7.23 APA (American Psychological Association) Style Nugraheni, R. W., Mulyadi, . N. A. & Yusuf, . H. (2020) Freeze-Dried Liposome Formulation for Small Molecules, Nucleic Acid, and Protein Delivery. Systematic Reviews in Pharmacy, 11 (7), 143-151. doi:10.31838/srp.2020.7.23 |
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