Gastro-Protective Effects of Epigallocatechin 3 ?Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study)

Abstract

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha.

Gastric ulcer disease is one of the major gastrointestinal diseases which occur because of unevenness between hostile and protective factors. Epigallocatechin 3 - gallate (EGCG) the most copious tea polyphenol is credited with anticancer, antidiabetic, and cardioprotective activities. The present examination was planned to assess the EGCG activity against pyloric ligation (PL) actuated gastric ulcer in rats.
Adult male albino rats, weighing 200g-250g were administered orally EGCG in two doses (5 mg/kg/day and 10 mg/kg/day) and ranitidine 80 mg/kg/day as a kind of perspective medication for seven consecutive days preceding subjection to PL.
The administration of EGCG in the two doses decreased the gastric injuries, ulcerative index, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), Caspase 3 (Casp-3) levels and increment the levels of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in a dose-dependent way. The immunohistochemical examination for an epidermal growth factor (EGF) demonstrated that EGCG increased EGF and diminished vascular endothelial growth factor (VEGF).
The ulcer defensive effect of EGCG was seen on the treated group and was compared to the ranitidine treated group; these effects might be because of its antioxidant, anti-inflammatory, and anti-apoptotic actions

How to Cite this Article
Pubmed Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). SRP. 2020; 11(12): 677-694. 
doi:10.31838/srp.2020.12.108

Web Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). http://www.sysrevpharm.org/?mno=32682 [Access: March 29, 2021]. doi:10.31838/srp.2020.12.108

AMA (American Medical Association) Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). SRP. 2020; 11(12): 677-694. doi:10.31838/srp.2020.12.108



Vancouver/ICMJE Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). SRP. (2020), [cited March 29, 2021]; 11(12): 677-694. doi:10.31838/srp.2020.12.108



Harvard Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha (2020) Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). SRP, 11 (12), 677-694. doi:10.31838/srp.2020.12.108



Turabian Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. 2020. Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). Systematic Reviews in Pharmacy, 11 (12), 677-694. doi:10.31838/srp.2020.12.108



Chicago Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. "Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study)." Systematic Reviews in Pharmacy 11 (2020), 677-694. doi:10.31838/srp.2020.12.108



MLA (The Modern Language Association) Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha. "Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study)." Systematic Reviews in Pharmacy 11.12 (2020), 677-694. Print. doi:10.31838/srp.2020.12.108



APA (American Psychological Association) Style

Ekram Nemr Abd Al Haleem, Gellan Alaa Mohamed, Azza Sayed Awad, Ragia Ali Taha (2020) Gastro-Protective Effects of Epigallocatechin 3 –Gallate: Impact on Anti-oxidant, Anti-Inflammatory, and Anti-Apoptotic Actions, (Invivo and Invitro Study). Systematic Reviews in Pharmacy, 11 (12), 677-694. doi:10.31838/srp.2020.12.108

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