Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia
Abstract
Dzul Fadly, Andi Hairil Alimuddin, Rukman Abdullah, Lili Amaliah, Rafdinal, Shifa Helena, Syarif Irwan Nurdiansyah, Warsidah.
Molluscs, apart from being a food ingredient, animals belonging to this class, also can be used as a source of potentially bioactive compounds. Shellfish are generally often used to treat liver disease. Thus, clam Meretrix meretrix may become a hepatoprotector. This research was conducted to determine the phytochemical components and hepatoprotective activity by measuring the levels of SGPT and SGOT from experimental animals that had been intervened by using ethanol extract of fresh and fermented clam Meretrix meretrix. The results of phytochemical screening showed the ethanol extract of the fresh sample only contained alkaloid compounds, and the ethanol extract of the fermented sample contained alkaloids, steroids, and saponins. The measurement of the SGPT value after treated with the sample extracts at concentrations of 100 ppm, 150 ppm, and 200 ppm for three days varied of 19.49 - 22.97 IU. The same also found in SGOT measurements after-treatment of the sample extracts at concentrations of 50 ppm, 100 ppm, and 150 ppm for three days, varied of 28.08 - 34.60. Our study revealed that ethanol extract from fresh and fermented clams showed a potential hepatoprotective activity, as seen from the effect of reducing SGPT and SGOT values after treatment for three days.
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| Pubmed Style Fadly D, Alimuddin AH, Abdullah R, Amaliah L, Rafdinal , Helena S, Nurdiansyah SI, Warsidah . Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. SRP. 2020; 11(9): 514-517. doi:10.31838/srp.2020.9.75 Web Style Fadly D, Alimuddin AH, Abdullah R, Amaliah L, Rafdinal , Helena S, Nurdiansyah SI, Warsidah . Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. http://www.sysrevpharm.org/?mno=13652 [Access: March 28, 2021]. doi:10.31838/srp.2020.9.75 AMA (American Medical Association) Style Fadly D, Alimuddin AH, Abdullah R, Amaliah L, Rafdinal , Helena S, Nurdiansyah SI, Warsidah . Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. SRP. 2020; 11(9): 514-517. doi:10.31838/srp.2020.9.75 Vancouver/ICMJE Style Fadly D, Alimuddin AH, Abdullah R, Amaliah L, Rafdinal , Helena S, Nurdiansyah SI, Warsidah . Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. SRP. (2020), [cited March 28, 2021]; 11(9): 514-517. doi:10.31838/srp.2020.9.75 Harvard Style Fadly, D., Alimuddin, . A. H., Abdullah, . R., Amaliah, . L., Rafdinal, ., Helena, . S., Nurdiansyah, . S. I. & Warsidah, . (2020) Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. SRP, 11 (9), 514-517. doi:10.31838/srp.2020.9.75 Turabian Style Fadly, Dzul, Andi Hairil Alimuddin, Rukman Abdullah, Lili Amaliah, Rafdinal, Shifa Helena, Syarif Irwan Nurdiansyah, and Warsidah. 2020. Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. Systematic Reviews in Pharmacy, 11 (9), 514-517. doi:10.31838/srp.2020.9.75 Chicago Style Fadly, Dzul, Andi Hairil Alimuddin, Rukman Abdullah, Lili Amaliah, Rafdinal, Shifa Helena, Syarif Irwan Nurdiansyah, and Warsidah. "Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia." Systematic Reviews in Pharmacy 11 (2020), 514-517. doi:10.31838/srp.2020.9.75 MLA (The Modern Language Association) Style Fadly, Dzul, Andi Hairil Alimuddin, Rukman Abdullah, Lili Amaliah, Rafdinal, Shifa Helena, Syarif Irwan Nurdiansyah, and Warsidah. "Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia." Systematic Reviews in Pharmacy 11.9 (2020), 514-517. Print. doi:10.31838/srp.2020.9.75 APA (American Psychological Association) Style Fadly, D., Alimuddin, . A. H., Abdullah, . R., Amaliah, . L., Rafdinal, ., Helena, . S., Nurdiansyah, . S. I. & Warsidah, . (2020) Hepatoprotective Activity of Ethanolic Extract of Fresh and Fermented Clam Meretrix meretrix from Kalimantan, Indonesia. Systematic Reviews in Pharmacy, 11 (9), 514-517. doi:10.31838/srp.2020.9.75 |
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