Histological Investigation Of The Effects Of Cinnamon Extract On Skin Of Male Sheep Affected By Mange

Abstract

Muna Hussain AL-Aameli, Yarub Modhar Al-Qazwini, Jabbar Abadi Mohammed.

The present study has been conducted to know the histological changes and the effects on the skin of male sheep caused by the parasite Psoroptes ovis and treatment with cinnamon alcoholic extract as an alternative to the traditional treatment. The animals experimental were used(n=28) divided two groups control sheep that represent one group (n=7) and infected sheep (n=21) were treated with three different concentrations (10, 30, 50 mg / l) of cinnamon alcoholic extract were second group. The results indicated the highest rate of recovery from injury (100% of the animals) achieved at a daily treatment with the concentration of 50 mg/l for a period of four weeks. As for the two concentrations of 10 and 30 mg / l, the recovery rates for the same period reached 30% and 40%, respectively. The results of the longitudinal analysis of histological changes in the infected sheep confirmed that the parasite caused severe changes of altered skin layers, major epidermal distortion characterized by hyper keratinizization and sloughing of the stratum corneum and stratum granulosum, along with many burrowing mites surrounded by inflammatory infiltrates of histiocytes. We also recorded moderate dermatitis of the sub-epidermis with abnormal architecture when compared with the control animals. However, these histological abnormalities were shifted back to the normal state as a result of the treatment with 50 mg/l of cinnamon extract. We conclude that the alcoholic extract of cinnamon with a concentration of 50 mg/l is a highly efficient alternative for the treatment of mange in animals, as clearly demonstrated by the 100% recovery rate and the restoration of the normal histological architecture.