Histopathological Changes In Placentas Due To Pregnancy-Induced Hypertension And Gestational Diabetes Compared With Normal Term Placenta

Abstract

Sawsan S. Hamzah, Ahmad Yar

Hypertension is the most commonly known problem of restoration during pregnancy, with up to 10% of pregnancies confused. Gestational diabetes mellitus is described as the occurrence or for the first time in pregnancy of a change in glucose levels to varying degrees. There are medical problems when diabetics and hypertension worsen pregnancy and affect maternal health.
Objectives: Analysis of unexplained placenta changes in patients with concomitant hypertension and gestational diabetes caused by pregnancy.
Materials and Methods: This study included forty placentas, twenty were collected from uncomplicated normotensive pregnant ladies, and the rest (20 placentas) were collected from ladies with concomitant gestational diabetes and pregnancy-induced hypertension. Histological sections were prepared using routine hæmotoxyline and eosin staining.
Results: The histomorphological study of placenta of patients with concomitant hypertension and diabetes mellitus showed a significant number of syncytial knots, stromal fibrosis, and the number of capillaries in terminal villi in Medium-sized diffusion areas of the vascular median cover.
Conclusion: Placenta examination is very important for the diagnosis of various pathological conditions, mechanisms are still far from well understood, but there is a common consensus that the pathological level depends on the type of diabetes and hypertension during pregnancy. This study provides an opinion of previous studies with a great association placental changes in patients with concomitant pregnancy-induced hypertension and diabetes. The clinical appearance and the magnitude of placental pathological changes were strongly associated. There is a wide range of microscopical changes noted as increased the numbers of the syncytial ganglia, fibrosis and the number of capillaries in the peripheral appendages