Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression
Abstract
Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein
ROS-1 protein is a transmembrane protein with a tyrosine kinase activity act as a growth or differentiation factor can derived cell proliferation acting as a proto-oncogen. It is expressed in the kidney and gastrointestinal tract and, in rare cases, in several other organs as well. Genetic rearrangements of ROS1 have been found in non-small cell lung cancer (NSCLC) and in other tumors as well like gastric carcinoma, ovarian carcinoma and others. This protein became of clinical interest because of the era of tyrosin kinase inhibitors role in treating cancer like crizotinib which have been approved for NSCLC with ROS1 alterations.
In this study we studied the immunohistochemical expression of ROS 1in mammary carcinoma in correlation with Hormonal receptor status (ER and PR) and Her2Neu expression.
Paraffin blocks of thirty cases of mammary ductal carcinoma were selelcted and studied by immunohistochemical staining for ER, PR, Her2Neu and ROS 1. Then the findings were analyzed statistically
Thirty-three percent of studied cases showed expression of ROS 1 which was assessed by stained cell proportion and cell staining intensity.
Neither stained cell proportion nor the staining intensity of ER and PR showed significant statistical correlation with ROS 1 expression . However a significant correlation was noted between ROS 1 expression and Her2Neu expression as 70% of ROS 1 positive cases were also positive for Her2Neu. This suggest a negative prognostic role of this protein in mammary carcinoma.
The finding of this relatively significant number of ROS 1 positive cases in mammary carcinoma can open the way for more understanding of mammary carcinoma pathogenesis and can open the way for the use of certain tyrosine kinase inhibitors in the most common type of female cancer.
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Pubmed Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. SRP. 2021; 12(1): 832-839. doi:10.31838/srp.2021.1.117 Web Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. http://www.sysrevpharm.org/?mno=45472 [Access: March 29, 2021]. doi:10.31838/srp.2021.1.117 AMA (American Medical Association) Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. SRP. 2021; 12(1): 832-839. doi:10.31838/srp.2021.1.117 Vancouver/ICMJE Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. SRP. (2021), [cited March 29, 2021]; 12(1): 832-839. doi:10.31838/srp.2021.1.117 Harvard Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein (2021) Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. SRP, 12 (1), 832-839. doi:10.31838/srp.2021.1.117 Turabian Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. 2021. Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. Systematic Reviews in Pharmacy, 12 (1), 832-839. doi:10.31838/srp.2021.1.117 Chicago Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. "Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression." Systematic Reviews in Pharmacy 12 (2021), 832-839. doi:10.31838/srp.2021.1.117 MLA (The Modern Language Association) Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein. "Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression." Systematic Reviews in Pharmacy 12.1 (2021), 832-839. Print. doi:10.31838/srp.2021.1.117 APA (American Psychological Association) Style Ameer Dh. Hameedi, Hassanien Gh. Hussein, Israa A. Hussein (2021) Immunohistochemical Expression Of ROS-1 In Mammary Ductal Carcinoma In Correlation With Hormonal Receptor Status And Her2Neu Expression. Systematic Reviews in Pharmacy, 12 (1), 832-839. doi:10.31838/srp.2021.1.117 |