Impact of Complications after Surgical Treatment of Colon Cancer on Survival

Abstract

Bekisheva Aizhan, Makishev Abai, Yoshihiro Noso.

Objective: The aim of our study was to analyze the postoperative complications by grouping into surgical and non-surgical as well as to study their impact on 5-year overall survival (OS) and 3-year disease free survival (DFS). Methods: A retrospective study was conducted 550 patients who underwent surgery for colon cancer between 2015-2019 in the “Multidisciplinary medical center” of the city Nur-Sultan (Kazakhstan). The cohort was divided into 3 groups: patients with surgical complications, non-surgical complications and no complications. The Kaplan-Meyer curve was made to compare OS and DFS between groups. Cox regression was used to study the effect of factors on survival. Results: In stage I colon cancer, the OS rate was 88.9% in the group without complications, 60% in the group with surgical complications, 65.5% in the group with non-surgical complications (p <0.05). DFS was 88.3%, 60% and 65.5%, respectively (p <0.05). In stage II colon cancer, OS rate was 85% in the group without complications, 60% in the group with surgical complications, 65% in the group with non-surgical complications (p <0.05). DFS was 85%, 59.4% and 50%, respectively (p <0.05). In stage III colon cancer, OS rate was 81.5% in the group without complications, 42.6% in the group with surgical complications, 59.3% in the group with non-surgical complications (p <0.05). DFS was 81.5%, 42.6% and 59.3%, respectively (p <0.05). In multivariate analysis, both surgical and non-surgical complications were found to be risk factors for decreased OS, as well as for decreased DFS. Conclusion: Surgical and non-surgical complications had a negative impact on OS and DFS.