Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment
Abstract
Sugiri Yani Jane, Loeki Enggar Fitri, Hani Susianti, Sumarno Reto Prawiro.
Background: In Drug-Resistant Tuberculosis (DR-TB), high IL17 level was corelated with severe tissue damage while low level was associated with mortality. High levels of IL-17 and IL - 23 were found in patients with a high bacterial load. TB treatment is carried out by combination of anti-tuberculosis drugs for a period of 9 to 24 months. This study aimed to analyze the differences in IL-17 and IL-23 levels before and after treatment compared to healthy controls, and their relationship with conversion AFB smear.
Methods: A prospective cohort study was conducted with total 38 subjects diagnosed as DR-TB using a molecular rapid test and 34 normal subjects as case and control groups. Examination of sputum AFB, IL-17 and IL-23 levels were carried out at the start of treatment and 30 days after treatment. Treatment was given in short term and individul drugs resistant regiments.
Results: The average levels of IL-17 and IL 23 before treatment compared to those after treatment showed no significant difference (p=0.153; p= 0.328). When compare to healthy controls group, the mean levels of IL-17 and IL 23 before treatment was not significantly different (p= 0.883; p= 0.928), whereas after 1 month treatment were significantly different (p= 0.047; p=0.042). An increase of IL-17 levels followed by an increase in IL-23 levels (p=0,000 r=.0.872). TB treatment affected the conversion rate of 97.4% with linear association.
Conclusion: The levels of IL-17 and IL-23 after treatment were increasing and significantly different with healthy group. These related with the high AFB conversion rate.
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| Pubmed Style Jane SY, Fitri LE, Susianti H, Prawiro SR. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. SRP. 2021; 12(1): 771-780. doi:10.31838/srp.2021.1.112 Web Style Jane SY, Fitri LE, Susianti H, Prawiro SR. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. http://www.sysrevpharm.org/?mno=44073 [Access: March 31, 2021]. doi:10.31838/srp.2021.1.112 AMA (American Medical Association) Style Jane SY, Fitri LE, Susianti H, Prawiro SR. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. SRP. 2021; 12(1): 771-780. doi:10.31838/srp.2021.1.112 Vancouver/ICMJE Style Jane SY, Fitri LE, Susianti H, Prawiro SR. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. SRP. (2021), [cited March 31, 2021]; 12(1): 771-780. doi:10.31838/srp.2021.1.112 Harvard Style Jane, S. Y., Fitri, . L. E., Susianti, . H. & Prawiro, . S. R. (2021) Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. SRP, 12 (1), 771-780. doi:10.31838/srp.2021.1.112 Turabian Style Jane, Sugiri Yani, Loeki Enggar Fitri, Hani Susianti, and Sumarno Reto Prawiro. 2021. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. Systematic Reviews in Pharmacy, 12 (1), 771-780. doi:10.31838/srp.2021.1.112 Chicago Style Jane, Sugiri Yani, Loeki Enggar Fitri, Hani Susianti, and Sumarno Reto Prawiro. "Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment." Systematic Reviews in Pharmacy 12 (2021), 771-780. doi:10.31838/srp.2021.1.112 MLA (The Modern Language Association) Style Jane, Sugiri Yani, Loeki Enggar Fitri, Hani Susianti, and Sumarno Reto Prawiro. "Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment." Systematic Reviews in Pharmacy 12.1 (2021), 771-780. Print. doi:10.31838/srp.2021.1.112 APA (American Psychological Association) Style Jane, S. Y., Fitri, . L. E., Susianti, . H. & Prawiro, . S. R. (2021) Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. Systematic Reviews in Pharmacy, 12 (1), 771-780. doi:10.31838/srp.2021.1.112 |
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