In-Silico Study Of Single Nucleotide Polymorphisms Concomitant By Polg2 Gene

Abstract

Maram Y. Al-Safarini, Hebatallah Abu Awwad.

In the knowledge of the genetic origin of several complicated human disorders, single-nucleotide polymorphisms (SNPs) play a prominent part. Also, understanding the roles of these SNPs may explain the biology of human phenotype heterogeneity. It would still be a big difficulty to describe the gene linked to disease, operational SNPs. We have studied the genetically variation in this study that can affect the expression and functioning of the POLG2 gene by utilizing the in-silico approaches. Among the total of 5828 SNPs, nonsynonymous (ns) SNPs were identified to be 341 and then 3 were recognized as pathogenic. Our analysis was able to classify the future prospects. nsSNPs which can be utilized for certain diseases that occur as just a genetic diagnostic tool. Although, as a disease prediction, the product of abnormality in the POLG2 structure and it is important to experimentally evaluate established nsSNPs. Our outcome showed that 1 nsSNP (rs104894632) exposed to -0.128 kcal/mol found to be pathogenic. Significant mutations from glycine to glutamic acid were established at positions 451 of the native POLG2 gene. We say that perhaps a nsSNP is based on a correlation of the stabilization sequences of native and mutant proteins (rs104894632) mitochondrial disorders induced by the POLG2 gene may be a significant candidate.