Interactions between Interleukin-6 and MDA in Women with Preeclampsia

Abstract

Abeer Nahy Hamdy, Maysoon Khaleefah Abbas, Maysaloon Ahmed Khudhair, Nihad Khalawe Tektook

This study is cross-sectional and conducted from March to July 2019 .in Baghdad city to compare the levels of IL-6 and MDA in healthy and preâ€�eclamptic pregnant wome. The number of pregnant women understudy were 60 women 30 normal pregnant women at the full term of pregnancy. Autamatic blood pressure monitoring was performed Blood pressure readings were taken at 30minute intervals. Blood were collected from each subject in this study, sera were then extracted and stored for determination of IL-6 and MDA by ELISA technique. The study showed no statistically variance between studied groups regarding patient age and gestational age at sampling and parity (P>0.05) while there was a significant difference between studied cases and the control group regarding systolic and diastolic blood pressure (P <0.05). The study presented that the highest mean level of MDA was found in pregnant women with preeclampsia (4.15±2.34 pg/ml) as compared with healthy women (1.71±0.44 pg/ml), (P<0.01). The study demonstrated that IL-6 mean was significantly elevated in pregnant women with Pre-eclampsia as compared with the control group (5.71±1.14 and 1.66 ± 0.41 pg/ml) respectively (P. value <0.01). The study showed strong positive correlation between MDA and IL-6 levels in pregnant women under preeclampsia