Investigating the anti-proliferation activity of Conocarpus erectus Against breast tumor cells in vitro

Abstract

Khulood M. Alsaraf, Maeda H. Mohammad Ahmed Majeed Al-Shammari and Ibrahim S. Abbas

The methanolic extract of Conocarpus erectus was tested in vitro on cancerous cell lines AMJ, MCF7, Cal51, and MDMBA and normal mouse embryonic fibroblast (MEF) cell line as a comparison. Morphological study for exposed cells was done by examination under phase-contrast inverted microscope. High-performance liquid chromatography (HPLC) was used to assay the concentrations of each component the phenols or flavonoids in the Conocarpus erectus methanol extract. Cell proliferation was reduced with concentrations after exposure time 72 h on AMJ and MDAMB cell line. Of contact there was fluctuation in the cell response to different concentrations of the extract on MCF7 and Cal51 cell line, compared with no effect on normal cell line (MEF). In conclusion, Conocarpus erectus has anticancer activity and may be considered a new source to use it in breast cancer therapy for future researches.