Journal: Systemic Review in Pharmacy The Interconnection of Metabolic Disorders and Carotid Atherosclerosis in the Kazakh Population
Kamshat M. AKHMETOVA, Tamara A. VOCHSHENKOVA, Erbolat D. DALENOV, Aigul A. ABDULDAYEVA, Valeriy V. BENBERIN.
Background: The mortality rate of cardiovascular disease (CVD) exceed mortality rates of other causes. Atherosclerosis (AS) as a result of chronic inflammation underlies death caused by CVD. Metabolic disorders are signs of AS. We studied the interconnection of metabolic disorders and carotid atherosclerosis in the Kazakh population.
Methods: The 399 Kazakh patients with AS participated in the study. The participants were divided into two groups according to levels of low-density lipoprotein (LDL), triglycerides (TG), and body mass index (BMI). Differences in the median value of glucose, lipid profile, white blood cells, uric acid, and BMI were studied in these groups.
Results: Lipid profile indicators were significantly higher in the 2nd group (Ñ€<0.001), which was divided based on LDL. In groups divided on TG and BMI basis, indicators of white blood cells, BMI, high-density lipoprotein, TG, glucose, uric acid, LDL, and total cholesterol (Ñ€<0.05) were higher than in the 2nd group. The number of plaques (3 and more) was 4.15% more among men than women. Lipid parameters were directly correlated with the number of plaques. The probability of occurrence of plaques increased with a high content of TG and BMI (Ñ€<0.05).
Conclusions: With hypertriglyceridemia and overweight, inflammatory processes and metabolic disorders proceed markedly. Dyslipidemia causes an increase in plaques in carotid arteries. Obesity and lipid profile parameters are specific prognostic markers for AS.