Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study
Abstract
Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy
Introduction: Down syndrome (DS) is one of the most common causes of intellectual disability. Many studies reported the relationship between antenatal history of spontaneous abortion and the risk of having DS children. Consanguineous marriage is common and preferrable in most of the Arabic countries, but its relation to DS remains controversial.
Objective: Evaluating the association between antenatal maternal history, spontaneous abortions and consanguineous marriage in relation to the risk of giving DS live births.
Subjects and Methods: This case control study included 306 patients diagnosed as DS, and their caregivers, presented to Clinical Genetics clinic, Cairo University Children Hospitals, from February 2018 to February 2020. The patients’ ages ranged from 1 to 5 years old and 306 families with healthy children as controls. They were evaluated by full history and examination.
Results: Among DS children 67.6% were males, 22% of mothers of DS gave history of antenatal illness. History of previous spontaneous abortions was statistically significant higher among mothers with DS children with P- value <0.001, while there was no statistical difference in the prevalence of consanguinity among families of DS and controls with P-value 0.186.
Conclusions: There is significant association between maternal history of spontaneous abortions and DS live births. However, there is no relationship between DS and consanguinity, these findings may be considered on providing genetic counselling.
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| Pubmed Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. SRP. 2021; 12(3): 76-79. doi:10.31838/srp.2021.3.13 Web Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. http://www.sysrevpharm.org/?mno=51496 [Access: March 30, 2021]. doi:10.31838/srp.2021.3.13 AMA (American Medical Association) Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. SRP. 2021; 12(3): 76-79. doi:10.31838/srp.2021.3.13 Vancouver/ICMJE Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. SRP. (2021), [cited March 30, 2021]; 12(3): 76-79. doi:10.31838/srp.2021.3.13 Harvard Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy (2021) Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. SRP, 12 (3), 76-79. doi:10.31838/srp.2021.3.13 Turabian Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. 2021. Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. Systematic Reviews in Pharmacy, 12 (3), 76-79. doi:10.31838/srp.2021.3.13 Chicago Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. "Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study." Systematic Reviews in Pharmacy 12 (2021), 76-79. doi:10.31838/srp.2021.3.13 MLA (The Modern Language Association) Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy. "Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study." Systematic Reviews in Pharmacy 12.3 (2021), 76-79. Print. doi:10.31838/srp.2021.3.13 APA (American Psychological Association) Style Radwa Ezzat Amin, Iman Ehsan Abdel-Meguid, Nihal Mohamed El-Refaie, Hala Ahmed El-Gindy (2021) Maternal Prenatal History And Consanguinity Among Families Of Children With Down Syndrome: A Retrospective Case Control Study. Systematic Reviews in Pharmacy, 12 (3), 76-79. doi:10.31838/srp.2021.3.13 |
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