Abstract

Sagar Kasar42735*

There are two basic types of topical drug delivery products, external topical and internal topical. Main advantages of topical drug delivery system are avoiding first pass metabolism, avoiding gastrointestinal incompatibilities, specific site selective, improving patient’s compliance, possible and easy self-medication, and drugs with short half-life and narrow therapeutic index are also subjected to be utilized, facility is used to easily terminate medicines whenever required. Micro-emulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and/or co-surfactant, have been studied as drug delivery systems because of their capacity to solubilize poorly water soluble drugs as well as their enhancement of topical and systemic availability.

It helps to solubilize the lipophilic drug moiety and it shows rapid and efficient penetration to the skin. So it is beneficial for topical drug delivery. Micro-emulgel is formulated by using phase transition and phase-inversion methods. Microemulgel system is evaluated for physical appearance, Compatibility studies, pH determination, rheological studies, globule size, extrudability, spreadability, drug content, skin irritation, ex-vivo bio-adhesive strength, in-vitro release, microbiological assays, and accelerated bioavailability studies.