Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules
Abstract
Amjid Iqbal.
It is well known that the diphosphate of ThDP is vital for the binding to the enzyme. However, this highly charged group is unsuitable for whole cell studies or pharmaceutical development, and compounds possessing it will suffer from poor bioavailability and cellular uptake. Various research groups have investigated the possibility to mimic the diphosphate with various neutral and more stable analogues without compromising too much binding affinity for the enzyme. This review discusses those efforts, which have been made to develop the identification of uncharged, chemically stable surrogates for the diphosphate linkage. Moreover, this field, is relevant not only to ThDP-dependent enzymes but also a wide range of other enzymes and proteins that bind diphosphate esters.
| How to Cite this Article |
| Pubmed Style Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. 2021; 12(2): 92-102. doi:10.31838/srp.2021.2.8 Web Style Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. http://www.sysrevpharm.org/?mno=64495 [Access: March 28, 2021]. doi:10.31838/srp.2021.2.8 AMA (American Medical Association) Style Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. 2021; 12(2): 92-102. doi:10.31838/srp.2021.2.8 Vancouver/ICMJE Style Amjid Iqbal. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP. (2021), [cited March 28, 2021]; 12(2): 92-102. doi:10.31838/srp.2021.2.8 Harvard Style Amjid Iqbal (2021) Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. SRP, 12 (2), 92-102. doi:10.31838/srp.2021.2.8 Turabian Style Amjid Iqbal. 2021. Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. Systematic Reviews in Pharmacy, 12 (2), 92-102. doi:10.31838/srp.2021.2.8 Chicago Style Amjid Iqbal. "Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules." Systematic Reviews in Pharmacy 12 (2021), 92-102. doi:10.31838/srp.2021.2.8 MLA (The Modern Language Association) Style Amjid Iqbal. "Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules." Systematic Reviews in Pharmacy 12.2 (2021), 92-102. Print. doi:10.31838/srp.2021.2.8 APA (American Psychological Association) Style Amjid Iqbal (2021) Mimics of Diphosphate in ThDP to Improve Pharmacokinetics of Potential Drug Molecules. Systematic Reviews in Pharmacy, 12 (2), 92-102. doi:10.31838/srp.2021.2.8 |
Abstract
PDF
How to cite this article
Related Records