Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock
Abstract
Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati
Background: Despite important advances in understanding the pathophysiology of sepsis, the mortality it generates remains high.
Objective: Describe the state of the art of molecular biomarkers proposed so far as potential markers for the diagnosis and prognosis of sepsis, severe sepsis and septic shock.
Results: The search yielded 3,370 references covering more than 30 genes with genetic polymorphisms that can be used as potential polymorphism markers. These were evaluated for its use in the different manifestations of sepsis, its diagnosis and progression. Twenty marker genes are described: four associated with bacteremia (TLR-1, TLR-2, Protein C and Selectin-E), nine with sepsis (IL-1B, IL-1A, IL-6, TNF-α, TLR-1, MBL-1, Hsp70, PAI-1 and MIF-1), seven with severe sepsis (IL-1RN, IL-10, TNF-α, CD14, TREM1, Caspasa 12 and DEFB-1), five with shock septic (TNF-B, TLR-4, Hsp70, MBL-1 and CD14) and three with dysfunction multi-organ (TLR-1, PAI-1 and Protein C).
Conclusion: Genetic polymorphisms, for the most part, have have been clinically proven as diagnostic markers and prognosis in sepsis with promising results due to discharge specificity and sensitivity in clinical practice.
| How to Cite this Article |
| Pubmed Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. 2020; 11(6): 101-111. doi:10.31838/srp.2020.6.18 Web Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. http://www.sysrevpharm.org/?mno=112585 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.18 AMA (American Medical Association) Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. 2020; 11(6): 101-111. doi:10.31838/srp.2020.6.18 Vancouver/ICMJE Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. (2020), [cited March 29, 2021]; 11(6): 101-111. doi:10.31838/srp.2020.6.18 Harvard Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati (2020) Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP, 11 (6), 101-111. doi:10.31838/srp.2020.6.18 Turabian Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. 2020. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy, 11 (6), 101-111. doi:10.31838/srp.2020.6.18 Chicago Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy 11 (2020), 101-111. doi:10.31838/srp.2020.6.18 MLA (The Modern Language Association) Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy 11.6 (2020), 101-111. Print. doi:10.31838/srp.2020.6.18 APA (American Psychological Association) Style Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati (2020) Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy, 11 (6), 101-111. doi:10.31838/srp.2020.6.18 |
Abstract
PDF
How to cite this article
Related Records