Monobactams as Anticancers: A Review Study
Cancer is a heterogeneous disease which categories as the second-leading cause of death worldwide. It is fatal to 42% of diagnosed patient every year. The ideal anticancer agents needed to be powerful, well tolerated in patients, with low side effect and high selectivity. Antibiotics on the other hand are efficient, well tolerated, with very low level of toxicity. Therefore, they continue to be the most important goal for new drugs invention. 2-Azetidinones (β-lactams) are most marketing drugs than any other antibiotics. The β-lactams provide unlimited choices of biological activities, and they efficaciously used as anticancer agent’s delivery system directly to the tumor sites as pro-drugs. These records indicate that the designation and synthesis of new monobactams will be favorable zone for improvement anticancer studying researches.