Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus

Abstract

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR.

This article presents experimental research and study of the peculiarities of alternative and reactive changes in the colon during prolonged exposure to the most widely used pesticides of various chemical groups (copper-containing, organochlorine, organophosphate) against the background of diabetes mellitus. The aim of the study was to identify morphological changes in the microcirculatory bed and tissue structures of the colon in chronic poisoning with pesticides "Neoron" and "Sumi-alpha" on the background of diabetes mellitus. Material and methods of research. The object of the study was the Ambassador of 68 white laboratory rats-males with an initial mass of 80-150 grams, who were in normal vivarium conditions. Modeling of alloxan diabetes was reproduced by a single intraperitoneal injection of 1.0 ml/100 g of alloxan in a phosphate-citrate buffer at the rate of 11 mg /100 g of mass. This study is retrospective, with historical data coverage, and prospective preclinical, experimental. Statistical processing of the obtained results was performed using standard student T-test methods to assess the reliability of differences using the SPSS-21 version program. The average values are represented as M±SD. Differences at p<0.05 were considered reliable. Results. Long-term periods are characterized by an increase in atrophic processes, leading to a noticeable thinning of the wall throughout. There were pronounced phenomena of crypt polymorphism, and glued crypts were found in some areas. In some places, as a result of massive desquamation of the epithelium, there was a Baring of mucosal areas, as well as ulcerative defects, around which there was a massive infiltration of leukocytes and macrophages. In such areas, the area of non-vascular zones increases, which worsens the course of pathomorphological processes. Conclusion. The data obtained by us indicate that in the early periods (3-15 days) after acute priming with pesticides "Neoron" and "Sumi-alpha", animals show pronounced inflammatory and destructive changes in all layers of the colon wall, especially the mucosa.

 

How to Cite this Article
Pubmed Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. SRP. 2020; 11(5): 701-704. 
doi:10.31838/srp.2020.5.100

Web Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. http://www.sysrevpharm.org/?mno=125901 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.100

AMA (American Medical Association) Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. SRP. 2020; 11(5): 701-704. doi:10.31838/srp.2020.5.100



Vancouver/ICMJE Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. SRP. (2020), [cited March 29, 2021]; 11(5): 701-704. doi:10.31838/srp.2020.5.100



Harvard Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR (2020) Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. SRP, 11 (5), 701-704. doi:10.31838/srp.2020.5.100



Turabian Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. 2020. Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (5), 701-704. doi:10.31838/srp.2020.5.100



Chicago Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. "Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus." Systematic Reviews in Pharmacy 11 (2020), 701-704. doi:10.31838/srp.2020.5.100



MLA (The Modern Language Association) Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR. "Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus." Systematic Reviews in Pharmacy 11.5 (2020), 701-704. Print. doi:10.31838/srp.2020.5.100



APA (American Psychological Association) Style

TUGANBAYEVA ALIYA, BEGIMBEKOVA LAZZAT, ALIYEVA ELNARA, OSPANOVA AKMARAL, UTEPOVA RAIKHAN, MUZDYBAYEVA GAUKHAR (2020) Morphological Condition of the Large Intestine in Chronic Intoxication with Pesticides Against the Background of Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (5), 701-704. doi:10.31838/srp.2020.5.100

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3
bandar togel terpercaya
agen togel terpercaya
situs togel bri online resmi terbaik dan terpercaya
aplikasi judi togel
daftar bandar lotre togel
bo togel deposit pulsa murah
Agen Togel Play Resmi
KEPO4D Toto Online Deposit Via Dana
bandar togel hadiah terbesar dan terpercaya DAPURTOTO
Daftar Togel Online Terbaik dan Terbesar
bandar togel terpercaya
agen togel online terpercaya
slot online gacor terbaik 2022 LAKU4D
bandar toto togel
Toto Togel laku4d
Situs Slot
Bandar Togel Online
Situs Bandar Togel
Bandar Togel 4D
Prediksi Togel Jitu
Situs Bandar Togel 4D
Bandar Togel 4D
Bandar Togel terlengkap
Bandar Togel online24jam
Bandar Togel hadiah 4d 10 juta
agen togel terpercaya
slot online dan judi bola dewa118
Situs Togel Online
Bandar Togel toto 4d terlengkap
data Sidney
toto slot
link alternatif situs togel
Situs Togel dan Toto Slot Online
bandar togel hadiah 4d 10 juta
toto hk
togel
data sdy
togel sgp
data togel sgp
bandar togel 4d dan slot deposit pulsa terpercaya
toto sgp
toto hk
togel hk
bandar togel
bandar togel 4d
togel 4d
situs togel deposit pulsa
toto online
BO Togel
BO Togel Toto HK
bandar togel 4d
totoslot 4d
situs togel resmi dan terpercaya
bandar togel bolak balik dibayar
agen togel online
Bandar Judi Mesin Slot Toto Togel 4D