Morphological, Immunophysiological And Clinical Features Of Respiration And Blood Circulation Under The Influence Of Combined Stress In The Covid-19 Conditions
K. M. Khamchiyev, F. M. Suleimenova, G.K. Sagimova, K.T. Adaibayev, A. F. Suchshenko, Ye.M. Serkesh.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19) has reached a pandemic level. There are now numerous indications that the COVID-19 coronavirus can severely affect the heart, blood vessels, nerves, brain, kidneys and skin. Of course, the lungs and airways are the main focus of attention with the COVID-19 respiratory disease. In this article the evaluation of pulmonary circulation indicators in the dynamics of respiratory cycle phases in intact animals was performed. This was done using self-registration method of reopulmonography in rats. In experiments on rats with the coloring of lungs tissue with hematoxylin and eosin were studied morphofunctional changes of pulmonary circulation during the combined influence of immobilization and hypothermia. It was determined that abnormalities run at the level of microvasculature vessels of lungs tissue and are accompanied by blood filling reduction, development of arteriolospasm signs, capillaries and post-capillary venules plethora with sustainable increase of vascular wall permeability.