Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae
Abstract
Amal Talib Al-Sa'ady and Falah H. Hussein.
For four months (1st October 2019 to 31st January 2020), fifty sputum specimens collected from patients with suspected pneumonia in AL-Hilla General Teaching Hospital and Babylon Hospital for Pediatric and Gynecology in Babylon Province, Iraq. Only 10 isolates of Streptococcus pneumoniae were isolated and identified. Depending on the results of antibacterial susceptibility test with 16 antibiotics by disc diffusion method, S. pneumoniae isolates have multi-drug resistance. Full resistance(100%) against erythromycin, Penicillin G and Amoxicillin, full sensitivity(100%) for vancomycin and moxifloxacin, 90% for each Sulfamethoxazole/Trimethoprim and Tetracycline, 80% for each Azithromycin and Amoxicillin/Clavulanic Acid, 70% for Clindamycin, 50% for each Ceftriaxone and Chloramphenicol, 30% for Ciprofloxacin, and 20% for each Levofloxacin, Cefepime and Meropenem. By using agar-well diffusion method the antibacterial activity of Titanium Dioxide Nanoparticles (TiO2NPs) against S. pneumoniae was determined in three concentrations: 20, 30, 40 μg/ml. TiO2NPs exhibit significant antibacterial efficacy in all concentrations while the biggest diameter of inhibition zone was measured in the higher concentration 40 µg/ml. MIC and MBC of TiO2 Nano-particles were evaluated by using two-fold serial dilutions method, MIC ≥50 μg/ml while MBC ≥100 μg/ml.
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| Pubmed Style Amal Talib Al-Saady and Falah H. Hussein. Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. SRP. 2020; 11(10): 53-63. doi:10.31838/srp.2020.10.11 Web Style Amal Talib Al-Saady and Falah H. Hussein. Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. http://www.sysrevpharm.org/?mno=9520 [Access: March 30, 2021]. doi:10.31838/srp.2020.10.11 AMA (American Medical Association) Style Amal Talib Al-Saady and Falah H. Hussein. Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. SRP. 2020; 11(10): 53-63. doi:10.31838/srp.2020.10.11 Vancouver/ICMJE Style Amal Talib Al-Saady and Falah H. Hussein. Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. SRP. (2020), [cited March 30, 2021]; 11(10): 53-63. doi:10.31838/srp.2020.10.11 Harvard Style Amal Talib Al-Saady and Falah H. Hussein (2020) Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. SRP, 11 (10), 53-63. doi:10.31838/srp.2020.10.11 Turabian Style Amal Talib Al-Saady and Falah H. Hussein. 2020. Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. Systematic Reviews in Pharmacy, 11 (10), 53-63. doi:10.31838/srp.2020.10.11 Chicago Style Amal Talib Al-Saady and Falah H. Hussein. "Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae." Systematic Reviews in Pharmacy 11 (2020), 53-63. doi:10.31838/srp.2020.10.11 MLA (The Modern Language Association) Style Amal Talib Al-Saady and Falah H. Hussein. "Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae." Systematic Reviews in Pharmacy 11.10 (2020), 53-63. Print. doi:10.31838/srp.2020.10.11 APA (American Psychological Association) Style Amal Talib Al-Saady and Falah H. Hussein (2020) Nanomedical Applications of Titanium Dioxide Nanoparticles as Antibacterial Agent against Multi-Drug Resistant Streptococcus Pneumoniae. Systematic Reviews in Pharmacy, 11 (10), 53-63. doi:10.31838/srp.2020.10.11 |
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