open-access
25+ Million Readerbase Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles
image image image image
Google Scholar citation report
Citations : 17406

Systematic Reviews in Pharmacy received 17406 citations as per google scholar report

Flyer image
Systematic Reviews in Pharmacy peer review process verified at publons
Flyer image

Indexed In

Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway

Abstract

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq

Renal ischemia reperfusion injury promotes tissue damage through inducing uncontrolled inflammation, oxidative stress and excessive renal tubular epithelial cell death. Nrf2 pathway is essential in protecting the kidney against renal IRI. Canagliflozin is a sodium glucose co-transporter 2 (SGLT2) inhibitor, Canagliflozin attenuated nephrotoxicity possibly through its anti-inflammatory and antioxidant effects and may confer reno-protective effects independently of its glycemic effects. To study the Nephroprotective potential effect of Canagliflozin renal ischemia reperfusion injury in rats model via modulation of Nrf2 pathway. In this study, adult male rats of Westar Albino type with 18-28 weeks in ageand weighing 300-350 g were randomized into equal four groups (6 rats each group) as following: Sham group, Control group, Vehicle (DMSO) group, Canagliflozin treated group. Rats were subject to bilateral renal ischemia for 30 min by clamping and reperfusion for 2 hr.We conclude that Canagliflozin significantly decrease renal ischemia reperfusion injury in rat model through Nrf2 pathway via it is pleiotropic effects as anti-oxidant, anti-inflammatory and anti-apoptotic.

How to Cite this Article
Pubmed Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. SRP. 2019; 10(2): 60-69. doi:10.5530/srp.2019.2.11

Web Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. http://www.sysrevpharm.org/?mno=302644926 [Access: March 31, 2021]. doi:10.5530/srp.2019.2.11

AMA (American Medical Association) Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. SRP. 2019; 10(2): 60-69. doi:10.5530/srp.2019.2.11


Vancouver/ICMJE Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. SRP. (2019), [cited March 31, 2021]; 10(2): 60-69. doi:10.5530/srp.2019.2.11


Harvard Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq (2019) Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. SRP, 10 (2), 60-69. doi:10.5530/srp.2019.2.11


Turabian Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. 2019. Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. Systematic Reviews in Pharmacy, 10 (2), 60-69. doi:10.5530/srp.2019.2.11


Chicago Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. "Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway." Systematic Reviews in Pharmacy 10 (2019), 60-69. doi:10.5530/srp.2019.2.11


MLA (The Modern Language Association) Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq. "Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway." Systematic Reviews in Pharmacy 10.2 (2019), 60-69. Print. doi:10.5530/srp.2019.2.11


APA (American Psychological Association) Style

Maryam Fahem Hassoon, Najah R Hadi, Waddah Mahboba, Dhafer Jawad, Yasmeen Ali Hussien, Maysaa Ali Abdulkhaleq (2019) Nephroprotective potential effect of Canagliflozin in renal ischemia reperfusion injury in rat model: Role of Nrf2 pathway. Systematic Reviews in Pharmacy, 10 (2), 60-69. doi:10.5530/srp.2019.2.11

ARTICLE TOOLS
Submit Article
Login
Register
Scan Code
Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3