New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology
Abstract
I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina
The biosynthesis of L-lysine-α-oxidase from Trichoderma harzianum Rifai F-180, an antitumor enzyme producer, was carried out on a wheat bran medium.
Hydrophilic bases of lightly crosslinked acrylic polymers and methylcellulose derivatives were selected, and model samples were prepared with a 1% concentration of the culture liquid of the fungus. The wound healing activity of the obtained gel samples was investigated on an experimental model of guinea pig wounds. The results of experimental studies showed a high wound healing activity of the gel with a 1% concentration of the culture liquid of the fungus and can serve as a basis for further preclinical trials of this dosage form of wound healing action.
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| Pubmed Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. SRP. 2020; 11(11): 203-207. doi:10.31838/srp.2020.11.29 Web Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. http://www.sysrevpharm.org/?mno=9799 [Access: March 29, 2021]. doi:10.31838/srp.2020.11.29 AMA (American Medical Association) Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. SRP. 2020; 11(11): 203-207. doi:10.31838/srp.2020.11.29 Vancouver/ICMJE Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. SRP. (2020), [cited March 29, 2021]; 11(11): 203-207. doi:10.31838/srp.2020.11.29 Harvard Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina, (2020) New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. SRP, 11 (11), 203-207. doi:10.31838/srp.2020.11.29 Turabian Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. 2020. New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. Systematic Reviews in Pharmacy, 11 (11), 203-207. doi:10.31838/srp.2020.11.29 Chicago Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. "New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology." Systematic Reviews in Pharmacy 11 (2020), 203-207. doi:10.31838/srp.2020.11.29 MLA (The Modern Language Association) Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina,. "New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology." Systematic Reviews in Pharmacy 11.11 (2020), 203-207. Print. doi:10.31838/srp.2020.11.29 APA (American Psychological Association) Style I.P. Smirnova, I.V. Podoprigora, V.I. Kuznetsov, T.I. Mansur, G.I. Miandina, N.V. Iashina, (2020) New Trichoderma harzianum Rifai F-180 - L-lysine--oxidase antitumor enzyme producer - culture liquid-based substance biotechnology. Systematic Reviews in Pharmacy, 11 (11), 203-207. doi:10.31838/srp.2020.11.29 |
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