Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem
Abstract
Rambhade SK, Singh S, Goswami RB, Rambhade A
This review aims to summarize the major advances of the preceding year and to put them into the context of current opinion on diabetes mellitus. Despite the advent of life-prolonging insulin for the treatment of diabetes, the appearance and progression of many of the disabling complications associated with this disease cannot be prevented through the administration of insulin. Clinically, the onset and rate of progression of diabetic complications, including cataract, corneal epitheliopathy, microangiopathy, nephropathy, neuropathy, and retinopathy, appear to be dependent upon both the duration and the severity of the diabetes. This review summarizes the specific pathogenic mechanisms of microvascular complications for which clinical therapies have been developed, including the polyol pathway, advanced glycation end products, protein kinase C, vascular epithelium growth factor, and the superoxide pathway. The review further focuses on therapies for these targets that are currently available or are undergoing late-stage clinical trials.
| How to Cite this Article |
| Pubmed Style Rambhade SK, Singh S, Goswami RB, Rambhade A. Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. SRP. 2011; 2(1): 8-18. doi:10.4103/0975-8453.83433 Web Style Rambhade SK, Singh S, Goswami RB, Rambhade A. Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. http://www.sysrevpharm.org/?mno=302644605 [Access: March 28, 2021]. doi:10.4103/0975-8453.83433 AMA (American Medical Association) Style Rambhade SK, Singh S, Goswami RB, Rambhade A. Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. SRP. 2011; 2(1): 8-18. doi:10.4103/0975-8453.83433 Vancouver/ICMJE Style Rambhade SK, Singh S, Goswami RB, Rambhade A. Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. SRP. (2011), [cited March 28, 2021]; 2(1): 8-18. doi:10.4103/0975-8453.83433 Harvard Style Rambhade SK, Singh S, Goswami RB, Rambhade A (2011) Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. SRP, 2 (1), 8-18. doi:10.4103/0975-8453.83433 Turabian Style Rambhade SK, Singh S, Goswami RB, Rambhade A. 2011. Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. Systematic Reviews in Pharmacy, 2 (1), 8-18. doi:10.4103/0975-8453.83433 Chicago Style Rambhade SK, Singh S, Goswami RB, Rambhade A. "Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem." Systematic Reviews in Pharmacy 2 (2011), 8-18. doi:10.4103/0975-8453.83433 MLA (The Modern Language Association) Style Rambhade SK, Singh S, Goswami RB, Rambhade A. "Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem." Systematic Reviews in Pharmacy 2.1 (2011), 8-18. Print. doi:10.4103/0975-8453.83433 APA (American Psychological Association) Style Rambhade SK, Singh S, Goswami RB, Rambhade A (2011) Occurrence, Complications, and Interventions of Diabetes: A New Understanding of an Old Problem. Systematic Reviews in Pharmacy, 2 (1), 8-18. doi:10.4103/0975-8453.83433< |
Abstract
PDF
How to cite this article
Related Records