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On the Issue of Modeling the Process of Metabolic Syndrome Regulation

Abstract

V.V. Benberin, T.A. Vochshenkova, A.S. Sibagatova, A.A. Nagimtaeva, K.M. Akhmetova, R.J. Karabaeva

Metabolic syndrome (hereinafter referred to as MS) is the main noncommunicable pandemic that determines the structure of cardiovascular morbidity and mortality. The reversibility of metabolic homeostasis disorders in MS provides a real opportunity to postpone the onset of associated diseases to a later date. The purpose of the study is to develop a conceptual model for regulation the development of MS. As part of the case-control study, 2 groups were formed out of 3000 participants - representatives of the Kazakh ethnic group in the third generation aged 20-60 years, selected randomly: the main group (with MS -1833 participants) and the control group (without MS -1167 participants). We compared 85 phenotypic traits and 114 single nucleotide polymorphisms (hereinafter referred to as SNPs) that had an impact on the risk of MS in other populations. The obtained results allowed us to see new opportunities in the management of MS symptoms, identify and evaluate the factors that are most significant for the risk of developing associated diseases prematurely. The regulation model proposed based on the concept of homeostasis maintenance uses early complex intervention at the level of modifiable risk factors. A clear advantage of the model over others is the active participation of the patient in the formation of their own health under the supervision of a consultant, mainly online. Its effectiveness will also be promoted by multi-factorism and dynamic development, providing an increasingly individual solution for a particular patient, as well as the medical and social nature of the concept.

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