Ophthalmic Drug Delivery System: Challenges and Approaches

Abstract

Patel PB, Shastri DH, Shelat PK, Shukla AK

Promising management of eye ailments take off effective concentration of drug at the eye for sufficient period of time. Ocular drug delivery is hampered by the barriers protecting the eye. The bioavailability of the active drug substance is often the major hurdle to overcome. Conventional ocular dosage form, including eye drops, are no longer sufficient to combat ocular diseases. This article reviews the constraints with conventional ocular therapy, essential factors in ocular pharmacokinetics, and explores various approaches like eye ointments, gel, viscosity enhancers, prodrug, penetration enhancers, microparticles, liposomes, niosomes, ocular inserts, implants, intravitreal injections, nanoparticles, nanosuspension, microemulsion, in situ-forming gel, iontophoresis, and periocular injections to improve the ocular bioavailability of drug and provide continuous and controlled release of the drug to the anterior and posterior chamber of the eye and selected pharmacological future challenges in ophthalmology. In near future, a great deal of attention will be paid to develop noninvasive sustained drug release for both anterior and posterior segment eye disorders. Current momentum in the invention of new drug delivery systems hold a promise toward much improved therapies for the treatment of visionthreatening disorders.

How to Cite this Article
Pubmed Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. SRP. 2010; 1(2): 114-120.
doi:10.4103/0975-8453.75042

Web Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. http://www.sysrevpharm.org/?mno=302644614 [Access: March 28, 2021]. doi:10.4103/0975-8453.75042

AMA (American Medical Association) Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. SRP. 2010; 1(2): 114-120. doi:10.4103/0975-8453.75042



Vancouver/ICMJE Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. Ophthalmic Drug Delivery System: Challenges and Approaches. SRP. (2010), [cited March 28, 2021]; 1(2): 114-120. doi:10.4103/0975-8453.75042



Harvard Style

Patel PB, Shastri DH, Shelat PK, Shukla AK (2010) Ophthalmic Drug Delivery System: Challenges and Approaches. SRP, 1 (2), 114-120. doi:10.4103/0975-8453.75042



Turabian Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. 2010. Ophthalmic Drug Delivery System: Challenges and Approaches. Systematic Reviews in Pharmacy, 1 (2), 114-120. doi:10.4103/0975-8453.75042



Chicago Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. "Ophthalmic Drug Delivery System: Challenges and Approaches." Systematic Reviews in Pharmacy 1 (2010), 114-120. doi:10.4103/0975-8453.75042



MLA (The Modern Language Association) Style

Patel PB, Shastri DH, Shelat PK, Shukla AK. "Ophthalmic Drug Delivery System: Challenges and Approaches." Systematic Reviews in Pharmacy 1.2 (2010), 114-120. Print. doi:10.4103/0975-8453.75042



APA (American Psychological Association) Style

Patel PB, Shastri DH, Shelat PK, Shukla AK (2010) Ophthalmic Drug Delivery System: Challenges and Approaches. Systematic Reviews in Pharmacy, 1 (2), 114-120. doi:10.4103/0975-8453.75042

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