Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties
Abstract
Zeina Althanoon, Ibrahim M Faisal, Abdulla A Ahmad, Marwan M. Merkhan.
Statins are group of hypolipidemic agents that are effective at lowering blood lipid levels subsequently improving ischemia associated pathology of atherosclerosis. This beneficial effect jointly linked to the members of statin and the miscellaneous effects they produce which is distinctly present with some statins but not others. These lipid lowering agents differ structurally and physically resulting in two group based on their hydrophobicity. Since, lipophilic penetrate readily across cell membrane, hydrophilic potentially needs a carrier and their volume of distribution is lower comparative to lipophilic statins. These structural and physicochemical variation ultimately result in variation in pharmacokinetic properties and could potentially carry an impact on their pharmacodynamics and the outcome of the therapeutic course. Moreover, variation in these properties could lead to repurposing of statin for new indications in the future.
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| Pubmed Style Althanoon Z, Faisal IM, Ahmad AA, Merkhan MM. Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. SRP. 2020; 11(7): 167-171. doi:10.31838/srp.2020.7.27 Web Style Althanoon Z, Faisal IM, Ahmad AA, Merkhan MM. Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. http://www.sysrevpharm.org/?mno=125679 [Access: March 28, 2021]. doi:10.31838/srp.2020.7.27 AMA (American Medical Association) Style Althanoon Z, Faisal IM, Ahmad AA, Merkhan MM. Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. SRP. 2020; 11(7): 167-171. doi:10.31838/srp.2020.7.27 Vancouver/ICMJE Style Althanoon Z, Faisal IM, Ahmad AA, Merkhan MM. Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. SRP. (2020), [cited March 28, 2021]; 11(7): 167-171. doi:10.31838/srp.2020.7.27 Harvard Style Althanoon, Z., Faisal, . I. M., Ahmad, . A. A. & Merkhan, . M. M. (2020) Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. SRP, 11 (7), 167-171. doi:10.31838/srp.2020.7.27 Turabian Style Althanoon, Zeina, Ibrahim M Faisal, Abdulla A Ahmad, and Marwan M. Merkhan. 2020. Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. Systematic Reviews in Pharmacy, 11 (7), 167-171. doi:10.31838/srp.2020.7.27 Chicago Style Althanoon, Zeina, Ibrahim M Faisal, Abdulla A Ahmad, and Marwan M. Merkhan. "Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties." Systematic Reviews in Pharmacy 11 (2020), 167-171. doi:10.31838/srp.2020.7.27 MLA (The Modern Language Association) Style Althanoon, Zeina, Ibrahim M Faisal, Abdulla A Ahmad, and Marwan M. Merkhan. "Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties." Systematic Reviews in Pharmacy 11.7 (2020), 167-171. Print. doi:10.31838/srp.2020.7.27 APA (American Psychological Association) Style Althanoon, Z., Faisal, . I. M., Ahmad, . A. A. & Merkhan, . M. M. (2020) Pharmacological Aspects of Statins Are Relevant to Their Structural and Physicochemical Properties. Systematic Reviews in Pharmacy, 11 (7), 167-171. doi:10.31838/srp.2020.7.27 |
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