Pharmacological Evaluation of Antidiabetic Activity of Chromolaena Odorata Leaves Extract in Streptozotocin-Induced Rats

Abstract

Hanifah Yusuf, Yusni Yusni, Firdalena Meutia, Marhami Fahriani.

Diabetes poses a public health burden range from the inadequacy of current therapies to complications. A new diabetic therapy derived from plants with less or no adverse effects is needed. Chromolaena odorata is commonly used as a traditional antidiabetic agent in some countries. The objective of this study was to evaluate the antidiabetic activity of C. odorata leaves extract in diabetic-induced rats. Six groups of Rattus novergicus were used: three concentrations of C. odorata leave extracts (100mg/kg body weight (BW), 200mg/kg BW, and 400mg/kg BW), normal control, diabetic control, and glibenclamide treatment group. C. odorata extract was administrated orally each day for five weeks. The animal body weight, blood glucose level, insulin level, and pathological changes of the pancreas were compared among groups. Data were analyzed using paired t-test or one-way ANOVA with post hoc analysis as appropriate. Our data indicated a significant difference in body weight between the diabetic group and all C. odorata treatment groups (p<0.05). There was a significant decline in blood glucose level in animals within C. odorata and glibenclamide group compared to diabetic control group. A significant increase in insulin level was also seen in animals within C. odorata groups compared to diabetic control animals. Beta cells regeneration was observed in animals treated with C. odorata extract. In conclusion, this study suggested that the ethanol extract of C. odorata leaves has antidiabetic activity. A study is warranted to identify the compound for further investigations.