Physiological And Histological Toxic Effects Of Different Doses Of Nandrolone Decanoate On The Kidney Of Male Mice

Abstract

Shaima Ahmed Rahim

Anabolic androgen steroids are widely used among athletes to increase muscles mass. Some patients with chronic kidney disease are also used these drugs. But the effect of these drugs on the kidney structure receives less attention.The current study was performed to investigate the histopathological effects of nandrolone decanoate injection in kidney tissues of adult male mice. Thirty adult male mice (balb / c) were randomly divided into three groups (10 mice in each group): two groups treated were injected subcutenously in the distled region of femur with 50 and 100 mg / kg b.w of Nandrolone Decanoate every 2 days for 4 weeks , while the control group was injected with 0.9% normal sline solution. Two physiological parameters were performed including urea and creatinine levels. The results showed that there was a significant increase (P <0.05) in kidney weights and also significant increase (P <0.05) in levels of urea and creatinine in all experimental groups compared with control group. All injected groups showed clear histological changes in the structure of the kidneys compared with the control group. These changes included a significant increase (P <0.05) in diameters of the Bowman's capsule, proximal, distal and collecting tubules in the experimental groups compared with control group. Moreover, certain pathological changes have been observed such as enlargement and increased cellularity of the renal glomeruli, degeneration of the lining epithelium of renal tubules, blood hemorrhage inside the tubules and congestion of the renal blood vessels with infiltration of the inflammatory cells. In this paper harmful toxic effects observed in the kidney’s tissues.